PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diglycol monoethyl ether acetate; (Carbitol acetate) | 112-15-2 |
15.01
11.01
7.01
8.00
4.09
4.07
3.08
3.05
10.00
3.09
|
||||||||||
| Formula | Synonyms | |||||||||||
| C8H16O4 | DIETHYLENE GLYCOL ETHYL ETHER ACETATE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 176.21 | L | -25 | 218.5 | 10.6 | 1.0096 @ 20°C | 10000 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.2 | 24 | 140 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 16 | 170 | 1000 |
Technical Basis
A review of available data sources identified the following: LD50 (rabbit1, rat2) toxicity values for inhalation and oral exposures. Each was evaluated using the guidelines for calculating equivalent values in the TEEL Handbook. Toxicity data were evaluated for their relative preference ranking3.
Although the rat oral LD50 is the most preferred, the rabbit oral LD50 source was more current and resulted in more conservative estimates, therefore it was selected as the starting point for the TEEL-3 value. TEEL-2 and TEEL-1 values were derived from this TEEL-3 according to guidance in the TEEL handbook4.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from rabbit, oral LD50 (4400 mg/kg)
This review generated TEEL values consistent with those published in Rev. 29A.
Although the rat oral LD50 is the most preferred, the rabbit oral LD50 source was more current and resulted in more conservative estimates, therefore it was selected as the starting point for the TEEL-3 value. TEEL-2 and TEEL-1 values were derived from this TEEL-3 according to guidance in the TEEL handbook4.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from rabbit, oral LD50 (4400 mg/kg)
This review generated TEEL values consistent with those published in Rev. 29A.
References
Rabbit, oral LD50: Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985., 2C (4027), 1982; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/8165#section=Acute-Effects
Rat, oral LD50: Union Carbide Data Sheet., 7/20/1965; via PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/8165#section=Acute-Effects
Species and route are ranked according to the preferences stated in Section 3.3.2, while the data selection hierarchy from Table 3.1.
Table 3.5.