PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Digoxin | 20830-75-5 |
4.07
4.08
7.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C41.H64.O14 | DIGOXIN, 12BETA-HYDROXYDIGITOXIN, ACYGOXIN, CARD-20(22)-ENOLIDE, 3-((O-2,6-DIDEOXY-BETA-D-RIBO- HEXOPYRA, CHLOROFORMIC DIGITALIN, CORDIOXIL, DAVOXIN, DIGACIN, DIGITALIS GLYCOSIDE, DIGITOXIN, 12BETA-HYDROXY-, DIGOSIN, DILANACIN, DIXINA, HOMOLLE^S DIGITALIN, LANACORDIN, LANATILIN, LANICOR, LANOCARDIN, LANOXIN, ROUGOXIN, SAROXIN, VANOXIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 781.05 | S |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.018 | 0.20 | 5.6 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.00056 | 0.0063 | 0.18 |
Technical Basis
A review of available sources identified a LOC and acute toxicity data (LD50, LDLo, TDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred rat toxicity data, an oral LD50, was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0002 gm/m3)
• TEEL-3 = Rat oral LD50 (28270 µg/kg)
This review generated a TEEL-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat intraperitoneal LD50; instead, the current TEEL-3 basis, a rat oral LD50, is a higher priority route (Section 3.3.2). The Rev. 29A and current TEEL-2 and TEEL-1 values, source, and methodology are consistent.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0002 gm/m3)
• TEEL-3 = Rat oral LD50 (28270 µg/kg)
This review generated a TEEL-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat intraperitoneal LD50; instead, the current TEEL-3 basis, a rat oral LD50, is a higher priority route (Section 3.3.2). The Rev. 29A and current TEEL-2 and TEEL-1 values, source, and methodology are consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Digoxin
Rat oral LD50. Archives Internationales de Pharmacodynamie et de Therapie., 164(47), 1966. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Digoxin
LOC. Appendix C, pg. C-4. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf