PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amino-1-propanol, 3- | 156-87-6 |
14.01
14.02
5.00
11.01
4.07
|
||||||||||
| Formula | Synonyms | |||||||||||
| C3H9NO | N-PROPANOLAMINE, 1-PROPANOL, 3-AMINO, 3-AMINO-1-PROPANOL, 3-PROPANOLAMINE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 75.13 | L | 187 | 2.1 | 60 | 0.9824 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 4.0 | 44 | 270 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.3 | 14 | 88 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most recent, lowest dose rat oral LD50 was selected as the TEEL-3 basis (Section 3.3.1). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1348 mg/kg)
This review generated PAC values that are inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both rat oral LD50 toxicity data, however the recommended value is based on a more conservative dose (1348 mg/kg vs. 2830 µll/kg). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remain consistent, with the differences in values due to the change of the TEEL-3 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1348 mg/kg)
This review generated PAC values that are inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are both rat oral LD50 toxicity data, however the recommended value is based on a more conservative dose (1348 mg/kg vs. 2830 µll/kg). The Rev. 29A and current TEEL-2 and TEEL-1 methodology remain consistent, with the differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/9086
Rat oral LD50 (1348 mg/kg), 1979. https://echa.europa.eu/de/registration-dossier/-/registered-dossier/13762/7/3/2/
Rat oral LD50 (2830 µl/kg), 1962. American Industrial Hygiene Association Journal., 23(95), 1962 [PMID:13914538]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/9086