A review of available sources identified rat and mouse toxicity LD50 toxicity data for oral and intraperitoneal exposures. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The data of the most preferred species and route, a rat oral LD50 from ECHA Europa, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (3327 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was mouse intraperitoneal LD50 that was located in this review; however, a higher priority rat oral LD50 was selected as the basis instead. The TEEL-1 and TEEL-2 methodology remain consistent, with the difference in values due to the change of the TEEL-3 basis.