PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Diisopropyl methylphosphonate 1445-75-6
14.01
4.01
7.01
8.00
6.00
4.07
4.08
7.00
3.02
5.10
Formula Synonyms
C7H17O3P
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
180.18 L 121.05 0.28 25 0.976 No temp
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
2.5 27 160
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.34 3.7 22
Technical Basis
A review of available sources found toxicity data for this chemical. A rat oral LD50 referenced across multiple sources (1978, 1991) was selected as the TEEL-3 basis. This value also resulted in the most conservative TEEL. TEEL-2 and TEEL-1 values were calculated from this TEEL-3, in accordance with guidelines in the handbook (Table 3.5.)

TEEL-1 = TEEL-2/11
TEEL-2 = TEEL-3/6
TEEL-3 = Rat oral LD50 (826 mg/kg)

This review generated values that are slightly more conservative than those reported in Rev. 29A. In Rev. 29A, the TEEL-3 toxicity starting point was reported as 928 mg/kg (ATSDR), however, this dose is not specified as an LD50 and it is from an older source (1976). The current recommendation is from multiple, more recent, and reputable sources, and its dose type is defined (LD50).
References
https://www.atsdr.cdc.gov/ToxProfiles/tp119.pdf
Department of Defense. 1991b. Cytogenetic testing on di-isopropylmethylphosphonate employing the rodent bone marrow micronucleus assay in male Fischer 344 rats. Aberdeen Proving Grounds, MD: U.S. Army Environmental Hygiene Agency. Contract no. DAAD05-89C-0224
https://pubchem.ncbi.nlm.nih.gov/substance/134979835#section=Acute-Effects
https://pubchem.ncbi.nlm.nih.gov/compound/3073
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