PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diisopropylbenzene, 1,3- | 99-62-7 |
5.10
7.00
7.01
7.11
3.10
7.10
3.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C12.H18 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 162.3 | L | -61 | 203.2 | 1 | 34.7 | 0.856 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 22 | 240 | 1500 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.3 | 36 | 230 |
Technical Basis
A review of available sources identified rat and mouse acute toxicity data (LD50) for various routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The LD50 of the most preferred route and species, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (7400 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 and TEEL-2 bases were a 2-hour rat LCLo and rat oral TDLo respectively, that were not found during this review. Instead, the recommended TEEL-3 was based on rat oral LD50 toxicity data, and the TEEL-2 was derived according to Table 3.5. The TEEL-1 methodology remains consistent, with the difference in value due to the change of the TEEL-2 basis.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (7400 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 and TEEL-2 bases were a 2-hour rat LCLo and rat oral TDLo respectively, that were not found during this review. Instead, the recommended TEEL-3 was based on rat oral LD50 toxicity data, and the TEEL-2 was derived according to Table 3.5. The TEEL-1 methodology remains consistent, with the difference in value due to the change of the TEEL-2 basis.
References
Chemical description: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-Diisopropylbenzene.
Rat oral LD50: Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(54), 1982. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-Diisopropylbenzene.