PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dimethoxybenzidene 3,3'-; (o-Dianisidine) | 119-90-4 |
11.01
4.09
4.10
2.00
3.09
3.02
3.10
16.01
16.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| C14H16N2O2 | 3,3^-DIMETHOXYBENZIDINE, 3,3'-DIANISIDINE, 3,3'-DIMETHOXY-4,4'-DIAMINOBIPHENYL, 3,3'-DIMETHOXY-4,4'-DIAMINODIPHENYL, 3,3'-DIMETHOXY-[1,1'-BIPHENYL]-4,4'-DIAMINE, 4,4'-BI-O-ANISIDINE, 4,4'-DIAMINO-3,3'-BIPHENYLDIOL DIMETHYL ETHER, 4,4'-DIAMINO-3,3'-DIMETHOXY-1,1'-BIPHENYL, 4,4'-DIAMINO-3,3'-DIMETHOXYBIPHENYL, ACETAMINE DIAZO BLACK RD, ACETAMINE DIAZO NAVY RD, AMACEL DEVELOPED NAVY SD, AZOENE FAST BLUE BASE, AZOENE FAST BLUE SALT, AZOFIX BLUE B SALT, AZOGENE FAST BLUE B, AZOGENE FAST BLUE B SALT, BENZIDINE, 3,3'-DIMETHOXY-, BIANISIDINE, BLUE BASE IRGA B, BLUE BASE NB, BLUE BN BASE, BLUE BN SALT, BLUE SALT NB, BRENTAMINE FAST BLUE B BASE, BRENTAMINE FAST BLUE B SALT, C.I. 37235, C.I. AZOIC DIAZO COMPONENT 48, C.I. AZOIC DIAZO COMPONENT 48, FAST BLUE B SALT, C.I. DISPERSE BLACK 6, C.I. DISPERSE BLACK 6, CELLITAZOL B, CELLITAZOL BN, CIBACETE DIAZO NAVY BLUE 2B, DI-P-AMINO-DI-M-METHOXYDIPHENYL, DI-PARA-AMINODI-META-METHOXYDIPHENYL, DIACEL NAVY DC, DIACELLITON FAST GREY G, DIANISIDINE, DIATO BLUE BASE B, DIATO BLUE SALT B, DIAZO FAST BLUE B, DMOB, FAST BLUE B BASE, FAST BLUE BASE B, FAST BLUE BN SALT, FAST BLUE DS SALT, FAST BLUE DSC BASE, FAST BLUE SALT B, FAST BLUE SALT BN, HILTONIL FAST BLUE B BASE, HILTOSAL FAST BLUE B SALT, HINDASOL BLUE B SALT, KAKO BLUE B SALT, KAYAKU BLUE B BASE, KAYAKU BLUE B SALT, LAKE BLUE B BASE, MEISEI TERYL DIAZO BLUE HR, MITSUI BLUE B BASE, MITSUI BLUE B SALT, NAPHTHANIL BLUE B BASE, NATASOL BLUE B SALT, NEUTROSEL NAVY BN, O,O'-DIANISIDINE, O-DIANISIDINE, SANYO FAST BLUE B SALT, SETACYL DIAZO NAVY R, SPECTROLENE BLUE B | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 244.29 | S | 137 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.030 | 63 | 380 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0030 | 6.3 | 38 |
Technical Basis
A review of available sources identified exposure limits (OEL-STEL and TWA) and acute toxicity data (LD50, LDLo, TDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred source and route, a rat oral LD50, was selected as the TEEL-3 basis (Table 3.1, Section 3.3.2). The TDLo was evaluated as a TEEL-2 source; however, it did not report acute toxic endpoints, so it was not selected. Instead, the TEEL-2 was derived according to Table 3.5. The available OEL-STEL was evaluated, and it was determined that it is not appropriate for TEEL development; instead, the lowest reported OEL-TWA (South Korea) was selected as the TEEL-1 basis.
• PAC-1 = TEEL-1 = OEL-TWA (0.01 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1920 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-3 source, and methodology are consistent. The Rev. 29A TEEL-2 basis was a rat TDLo identified during this review, but not selected because it does not report acute toxic effects (Section 3.3.2); instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is an OEL-TWA.
• PAC-1 = TEEL-1 = OEL-TWA (0.01 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1920 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-3 source, and methodology are consistent. The Rev. 29A TEEL-2 basis was a rat TDLo identified during this review, but not selected because it does not report acute toxic effects (Section 3.3.2); instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 basis is an OEL-TWA.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Dianisidine
Rat oral LD50. Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986, (723), 1986. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Dianisidine.
Rat oral TDLo: TOSCF2 53,71,2000. Retrieved from: https://www.cdc.gov/niosh-rtecs/DDD59F8.html
OELs: https://ilv.ifa.dguv.de/limitvalues/21545