PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dimethyl-1,3-propanediamine, N,N-; (1-Amino-3-dimethylaminopropane) | 109-55-7 | 1993 |
11.01
11.00
4.07
4.01
14.01
14.02
7.01
|
|||||||||
| Formula | Synonyms | |||||||||||
| C5.H14.N2 | DIMETHYLAMINOPROPYLAMINE, (3-AMINOPROPYL)DIMETHYLAMINE, 1-(DIMETHYLAMINO)-3-AMINOPROPANE, 1-AMINO-3-(DIMETHYLAMINO)PROPANE, 1-AMINO-3-DIMETHYLAMINOPROPANE, 3-(DIMETHYLAMINE)PROPYLAMINE, 3-(DIMETHYLAMINO)-1-AMINOPROPANE, 3-(DIMETHYLAMINO)-1-PROPANAMINE, 3-(DIMETHYLAMINO)-1-PROPYLAMINE, 3-(DIMETHYLAMINO)PROPANAMINE, 3-(DIMETHYLAMINO)PROPYLAMINE, 3-(N,N-DIMETHYLAMINO)PROPYLAMINE, 3-AMINO-1-(DIMETHYLAMINO)PROPANE, 3-DIMETHYLAMINOPROPYLAMINE, 3-N,N-DIMETHYLAMINOPROPYLAMINE, GAMMA-DIMETHYLAMINOPROPYLAMINE, N,N-DIMETHYL-1,3-DIAMINOPROPANE, N,N-DIMETHYL-1,3-PROPANEDIAMINE, N,N-DIMETHYL-1,3-PROPYLENEDIAMINE, N,N-DIMETHYL-N-(3-AMINOPROPYL)AMINE, N,N-DIMETHYLPROPYLENEDIAMINE, N,N-DIMETHYLTRIMETHYLENEDIAMINE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 102.21 | L | 123 | 10 | 30 | 0.8100 @ 30°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.0 | 14 | 81 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.4 | 3.3 | 19 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species and routes, and exposure limits (OEL-TWA). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Two preferred rat oral LD50 toxicity data (410 mg/kg and 1870 mg/kg) were evaluated for the TEEL-3 basis and the most conservative dose (a combined male/female dose), was selected. The TEEL-2 value was derived according to Table 3.5. The OEL-TWA (Canada-Ontario) was selected as the TEEL-1 basis.
• PAC-1 = TEEL-1 = OEL-TWA x 3 (Canada-Ontario, 2 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (410 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50; however, the current value is based on a more conservative dose. The Rev. 29A TEEL-2 basis was a rat oral TDLo that was not found in this review; instead, it was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5) while the current basis is an exposure limit, an OEL-TWA.
• PAC-1 = TEEL-1 = OEL-TWA x 3 (Canada-Ontario, 2 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (410 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50; however, the current value is based on a more conservative dose. The Rev. 29A TEEL-2 basis was a rat oral TDLo that was not found in this review; instead, it was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the TEEL-2 (Table 3.5) while the current basis is an exposure limit, an OEL-TWA.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/3-Dimethylaminopropylamine.
OEL-TWA: https://ilv.ifa.dguv.de/limitvalues/21958
Rat LD50 (combined sex dose; 410 mg/kg): https://chem.echa.europa.eu/100.003.347/dossier-view/72a7349d-7071-470f-94e1-f4189a1a3497/IUC5-b88f2a93-ff8e-474c-9a4a-7b488c8bd084_03fb516f-4910-460c-84fe-cf14acd44f15?searchText=109-55-7
Rat oral LD50 (1870 mg/kg): American Industrial Hygiene Association Journal., 23(95), 1962 [PMID:13914538]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/3-Dimethylaminopropylamine.