A review of available sources identified acute toxicity data (LD50, LDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species toxicity data, D rat intraperitoneal LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat intraperitoneal LD50 (620 mg/kg)
This review generated PAC-1 and PAC-2 values inconsistent with Rev. 29A and a consistent PAC-3 value. The Rev. 29A and current TEEL-3 source and methodology are consistent. The Rev. 29A TEEL-2 basis was a rat intraperitoneal TDLo that was not identified in this review; instead, the current TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in TEEL-2.