PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Dioxathion 78-34-2 3018
6.00
4.01
4.05
7.01
7.00
11.00
4.07
7.11
3.02
16.01
Formula Synonyms
C12.H26.O6.P2.S4 DIOXATHION, 1,4-DIOXAN-2,3-DIYL BIS(O,O-DIETHYL PHOSPHOROTHIOLOTHIONATE), 1,4-DIOXAN-2,3-DIYL BIS(O,O-DIETHYLPHOSPHOROTHIOLOTHIONATE), 1,4-DIOXAN-2,3-DIYL O,O,O^,O'-TETRAETHYL DI(PHOSPHORODITHIOA, 1,4-DIOXAN-2,3-DIYL O,O,O',O'-TETRAETHYL DI(PHOSPHOROMITHIOA, 1,4-DIOXANE- 2,3-S,S'-BIS(O,O-DIETHYL DITHIOPHOSPHATE), 2,3- DIOXANEDITHIOL S,S-BIS(O,O-DIETHYL PHOSPHORODITHIOATE), 2,3-BIS(DIETHOXYPHOSPHINOTHIOYLTHIO)- 1,4-DIOXANE, 2,3-BIS(DIETHOXYPHOSPHINOTHIOYLTHIO)-1,4-DIOXANE, 2,3-DIOXANE S,S-BIS(O,O-DIETHYLPHOSPHORODITHIOATE), 2,3-P-DIOXANDITHIOL S,S-BIS(O,O-DIETHYLPHOSPHORODITHIOATE), 2,3-P-DIOXANE S,S-BIS(O,O-DIETHYLPHOSPHORODITHIOATE), 2,3-P-DIOXANEDITHIOL S,S-BIS(O,O-DIETHYL PHOSPHORODITHIOATE), 2,3-P-DIOXANETHIOL S,S-BIS(O,O-DIETHYL PHOSPHORO-DITHIOATE), AC 528, BERCOTOX, DELNATEX, DELNAV, DELNAV®, DELTIC, DIOXANE PHOSPHATE, DIOXATION, DIOXOTHION, ENT 22,897, ENT 22879, ENT 22897, HERCULES 528, HERCULES AC528, KAVADEL, NAVADEL, NAVADEL®, NCI-C00395, P-DIOXANE-2,3-DITHIOL, S,S-DIESTER WITH O,O-DIETHYL PHOSHORO, P-DIOXANE-2,3-DITHIOL, S,S-DIESTER WITH O,O-DIETHYL PHOSPHOR, P-DIOXANE-2,3-DIYL ETHYL PHOSPHORODITHIOATE, PHOSPHORODITHIOIC ACID S,S'-1,4-DIOXANE-2,3-DIYL O,O,O',O'-T, PHOSPHORODITHIOIC ACID S,S'-P-DIOXANE-2,3-DIYL O,O,O',O'-TET, PHOSPHORODITHIOIC ACID, S,S'-1,4-DIOXANE-2,3-DIYL O,O,O',O'-, PHOSPHORODITHIOIC ACID, S,S'-P-DIOXANE-2,3-DIYL O,O,O',O'-TE, RUPHOS
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
456.56 L -20 1.257 @ 26°C
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.40 3.4 39
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.021 0.18 2.1
Technical Basis
A review of available sources identified the following: OEL-STELs, OEL-TWAs, LOC, and acute toxicity data (LC50, LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The data of the most preferred exposure and species, a rat LC50, was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The OEL-STEL (Austria/Denmark) was selected as the TEEL-1.
• TEEL-1 = OEL-STEL (Austria and Denmark, 0.4 mg/m3)
• TEEL-2 = LOC (0.0034 g/m3)
• TEEL-3 = Rat LC50 (1398 mg/m3/1H)
This review generated TEEL-2 and TEEL-3 values that are consistent with Rev. 29A. There are no changes to the TEEL-2 and TEEL-3 values or methodology, which remain based on the highest priority exposure limit, the LOC, and acute toxicity data, a rat LC50, respectively. In Rev. 29A the TEEL-1 was derived from the LOC, however, this review found and used an OEL-STEL.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Dioxathion
Rat LC50: Toxicology and Applied Pharmacology., 5(605), 1963. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Dioxathion
OEL-STELs: https://ilv.ifa.dguv.de/limitvalues/23884
LOC: Appendix C, page C-4; https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
Search Again
PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.