PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TCDD; (2,3,7,8-Tetrachlorodibenzo-p-dioxin; Dioxin) | 1746-01-6 | 2811 |
13.00
15.01
4.01
11.01
15.02
4.08
4.05
7.01
8.00
11.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C12H4Cl4O2 | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD), 2,3,6,7-TETRACHLORODIBENZO-P-DIOXIN, 2,3,6,7-TETRACHLORODIBENZOIDIOXIN, 2,3,7,8-TCDD, 2,3,7,8-TETRACHLORODIBENZO(B,E)(1,4)DIOXIN, 2,3,7,8-TETRACHLORODIBENZO-1,4-DIOXIN, 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, 2,3,7,8-TETRACHLORODIBENZO[B,E][1,4]DIOXIN, AROMATIC HYDROCARBON RECEPTOR (HUMAN CLONE HU14), DIBENZO-P-DIOXIN, 2,3,7,8-TETRACHLORO-, DIOXIN, DIOXIN (HERBICIDE CONTAMINANT), DIOXINE, NCI-C03714, TCDBD, TCDD, TETRACHLORODIBENZODIOXIN, TETRADIOXIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 321.97 | S | 295 | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.00013 | 0.0014 | 0.0085 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0000099 | 0.00011 | 0.00065 |
Technical Basis
A review of available sources identified numerous animal toxicity sources, from which the oral LD50 of the most preferred species (dog, monkey, and rat,) were evaluated. Many lowest reported toxicities (human and animal) were also identified; however, none reported suitable toxicity end points for TEEL development. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected based on the type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Of the sources selected for additional evaluation, three are reported from the same source (PMID:6813132); when investigated further, it was determined that a different source reported a rat oral LD50 (43 µg/kg) that was more reliable and recent. This rat oral LD50¬ was selected as the TEEL-3 basis. No independent source was identified as a basis for TEEL-2 or TEEL-1; therefore, these values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (43 µg/kg)
This review generated TEEL values consistent with those in Rev. 29A. This chemical is the chemical reference for deriving dioxin and dioxin-like compounds (DLCs) in the TEEL database.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (43 µg/kg)
This review generated TEEL values consistent with those in Rev. 29A. This chemical is the chemical reference for deriving dioxin and dioxin-like compounds (DLCs) in the TEEL database.
References
Dog oral LD50 (1 µg/mg); Experientia., 38(879), 1982 [PMID:6813132]. Retrieved from Section 12.1.15 Acute Effects from: https://pubchem.ncbi.nlm.nih.gov/compound/2_3_7_8-Tetrachlorodibenzo-P-dioxin.
Monkey oral LD50 (2 µg/kg); Experientia., 38(879), 1982 [PMID:6813132]. Retrieved from Section 12.1.15 Acute Effects from: https://pubchem.ncbi.nlm.nih.gov/compound/2_3_7_8-Tetrachlorodibenzo-P-dioxin.
Rat oral LD50 (20 µg/kg); Experientia., 38(879), 1982 [PMID:6813132]. Retrieved from Section 12.1.15 Acute Effects from: https://pubchem.ncbi.nlm.nih.gov/compound/2_3_7_8-Tetrachlorodibenzo-P-dioxin.
Rat (Sprague-Dawley) oral LD50 (43 µg/kg); Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 305. Retrieved from Section 4.4 Non-Human Toxicity Values (Complete) from: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4151