PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aminoethylpiperazine, N- | 140-31-8 | 2815 |
14.01
4.01
11.01
14.02
7.01
11.00
4.07
5.00
4.11
|
|||||||||
| Formula | Synonyms | |||||||||||
| C6H15N3 | N-AMINOETHYLPIPERAZINE, 1-(2-AMINOETHYL) PIPERAZINE, 1-(2-AMINOETHYL)PIPERAZINE, 1-(BETA-AMINOETHYL)PIPERAZINE, 1-PIPERAZINE ETHANAMINE, 1-PIPERAZINEETHYLAMINE, 2-(1-PIPERAZINYL)ETHYLAMINE, 2-PIPERAZINYLETHYLAMINE, 4-(2-AMINOETHYL)PIPERAZINE, AEP, ANCAMINE AEP, N-(2-AMINOETHYL) PIPERAZINE, N-(2-AMINOETHYL)PIPERAZINE, N-(BETA-AMINOETHYL)PIPERAZINE, N-AMINOETHYL PIPERAZINE, N-AMINOÉTHYLPIPÉRAZINE (DOT FRENCH), N-AMINOETILPIPERAZINA (DOT SPANISH), PIPERAZINE, 1-(2-AMINOETHYL)-, USAF DO-46 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 129.203 | L | 17.6 | 220 | 0.985 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.3 | 69 | 420 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.2 | 13 | 79 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species (rat, mouse, rabbit) and routes (oral, intraperitoneal, dermal). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Two preferred rat oral LD50 toxicity data were evaluated for the TEEL-3 basis (2140 uL/kg converted to 2107.9 mg/kg with density = 0.985, and 2097 mg/kg), and the most conservative dose (2097 mg/kg) was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2097 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A, and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-2 and TEEL-1 sources and methodologies remain consistent; therefore, minor differences may be due to rounding.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2097 mg/kg)
This review generated a PAC-3 value consistent with Rev. 29A, and inconsistent PAC-2 and PAC-1 values. The Rev. 29A and current TEEL-2 and TEEL-1 sources and methodologies remain consistent; therefore, minor differences may be due to rounding.
References
Chemical information and density: https://pubchem.ncbi.nlm.nih.gov/compound/1-_2-Aminoethyl_piperazine.
Rat oral LD50 (2097 mg/kg): https://echa.europa.eu/de/registration-dossier/-/registered-dossier/16054/7/3/2
Rat oral LD50 (2140 uL/kg): Union Carbide Data Sheet., 6/13/1969. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1-_2-Aminoethyl_piperazine.