PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Diphenylguanidine, 1,3- | 102-06-7 | 8027 |
15.01
4.05
7.00
11.00
4.09
4.06
4.10
4.07
3.08
7.10
|
|||||||||
| Formula | Synonyms | |||||||||||
| C13H13N3 | 1,3-DIPHENYLGUANIDINE, 1,2-DIPHENYLGUANIDINE, ACCEL DM-R, ACCELERATOR D, CHLOROSTAIN BR, DENAX, DENAX DPG, DFG, DIPHENYLGUANIDINE, DPG, DPG ACCELERATOR, GUANIDINE, 1,3-DIPHENYL-, MELANILINE, N,N^-DIPHENYLGUANIDINE, NCI-C60924, NOCCELER D, PERKACIT DP, RHENOGRAN DPG, SANCELER D, SOXINOL D, SYM-DIPHENYLGUANIDINE, USAF B-19, USAF EK-1270, VANAX DPG, VULCACID D, VULCAFOR DPG, VULKACIT D, VULKACIT D/C, VULKACITE D, VULKAZIT | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 211.29 | S | 150 | 1.13 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.32 | 3.5 | 21 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.037 | 0.41 | 2.4 |
Technical Basis
A review of available sources identified several acute toxicity data (LD50, LDLo) for various routes and species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Two preferred rat oral LD50 (107 mg/kg and 323 mg/kg) were evaluated for the TEEL-3 basis, and the more conservative dose was selected. The dose, from ECHA Europa, was reported as a range (107-111 mg/kg), therefore the lower limit of the range was used for TEEL calculations. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (107 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 that was identified during this review; however, this current TEEL-3 basis is a more conservative rat oral LD50 dose. The TEEL-1 and TEEL-2 use the same methodology, with differences due to the change in TEEL-3.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (107 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 that was identified during this review; however, this current TEEL-3 basis is a more conservative rat oral LD50 dose. The TEEL-1 and TEEL-2 use the same methodology, with differences due to the change in TEEL-3.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-Diphenylguanidine.
Rat oral LD50 (107 mg/kg): https://echa.europa.eu/de/registration-dossier/-/registered-dossier/14992/7/3/1
Rat oral LD50 (323 mg/kg): National Toxicology Program Technical Report Series., NIH-95-3933. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/1_3-Diphenylguanidine.