PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disulfiram | 97-77-8 |
4.08
4.05
7.01
8.00
7.00
4.06
4.04
4.10
4.07
3.08
|
||||||||||
| Formula | Synonyms | |||||||||||
| C10.H20.N2.S4 | TETRAETHYLTHIURAM DISULFIDE, 1,1^-DITHIOBIS(N,N-DIETHYLTHIOFORMAMIDE), ABSTENSIL, ABSTINIL, ABSTINYL, ACCEL TET, ALCOPHOBIN, ALK-AUBS, ANTABUS, ANTABUSE, ANTABUSE®, ANTADIX, ANTAENYL, ANTAETHAN, ANTAETHYL, ANTAETIL, ANTALCOL, ANTETAN, ANTETHYL, ANTETIL, ANTEYL, ANTI-ETHYL, ANTIAETHAN, ANTICOL, ANTIETANOL, ANTIETIL, ANTIKOL, ANTIVITIUM, AVERSAN, AVERZAN, BIS((DIETHYLAMINO)THIOXOMETHYL)DISULPHIDE, BIS(DIETHYLTHIOCARBAMOYL) DISULFIDE, BIS(DIETHYLTHIOCARBAMOYL)DISULPHIDE, BIS(N,N-DIETHYLTHIOCARBAMOYL) DISULFIDE, BIS(N,N-DIETHYLTHIOCARBAMOYL)DISULPHIDE, BONIBAL, CONTRALIN, CONTRAPOT, CRONETAL, DICUPRAL, DISETIL, DISULFAN, DISULFIDE, BIS(DIETHYLTHIOCARBAMOYL), DISULFIRAM, DISULFURAM, DISULPHURAM, EKAGOM DTET, EKAGOM TEDS, EKAGOM TETDS, EPHORRAN, ESPENAL, ESPERAL, ETABUS, ETHYL THIRAM, ETHYL THIUDAD, ETHYL THIURAD, ETHYL TUADS, ETHYL TUEX, ETHYLDITHIOURAME, ETHYLDITHIURAME, EXHORAN, EXHORRAN, HOCA, KROTENAL, N,N,N',N',-TETRAETHYLTHIURAM DISULPHIDE, N,N,N',N'-TETRAETHYLTHIURAM DISULFIDE, NCI-C02959, NOCBIN, NOCCELER TET, NOXAL, NSC 25953, REFUSAL, RO-SULFIRAM, RO-SULFIRAM®, SANCELER TET, SANCELER TET-G, SOXINOL TET, STOPAETHYL, STOPETHYL, STOPETYL, TATD, TENURID, TENUTEX, TETD, TETIDIS, TETRADIN, TETRADINE, TETRAETHYLTHIOPEROXYDICARBONIC DIAMIDE, TETRAETHYLTHIRAM DISULFIDE, TETRAETHYLTHIRAM DISULPHIDE, TETRAETHYLTHIURAM, TETRAETHYLTHIURAM DISULPHIDE, TETRAETHYLTHIURAM SULFIDE, TETRAETIL, TETURAM, TETURAMIN, THIOSAN, THIOSCABIN, THIRERANIDE, THIURAM E, THIURANIDE, TILLRAM, TIURAM, TTD, TTS, USAF B-33 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 296.56 | S | 70 | 117 | 1.3 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.0 | 17 | 99 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.16 | 1.4 | 8.2 |
Technical Basis
A review of available sources identified several acute toxicity data (LDLo, LD50, TDLo) and exposure limits (OEL-STELs, MAK-STEL, TWAs). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Multiple human (male & female) oral LDLo and TDLo toxicity data were available for the TEEL-3 and TEEL-2 bases; however, they were intermittent exposures ranging from two to six weeks. Instead, higher priority LD50 data were evaluated for the TEEL-3 basis, and the most preferred species, a rat oral LD50, was selected. The TEEL-2 value was derived according to Table 3.5. A 15-minute OEL-STEL (Sweden) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = OEL-STEL (Sweden, 2 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (500 mg/kg)
This review generated PAC-2 and PAC-3 values consistent with Rev. 29A and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA while the current TEEL-1 is an OEL-STEL (see Note, Table 3.5). The TEEL-3 and TEEL-2 values, source, and methodology are consistent.
• PAC-1 = TEEL-1 = OEL-STEL (Sweden, 2 mg/m3)
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (500 mg/kg)
This review generated PAC-2 and PAC-3 values consistent with Rev. 29A and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA while the current TEEL-1 is an OEL-STEL (see Note, Table 3.5). The TEEL-3 and TEEL-2 values, source, and methodology are consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Disulfiram.
OEL-STEL: https://ilv.ifa.dguv.de/limitvalues/24853
Rat LD50: Archiv fuer Toxikologie., 22(12), 1966. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Disulfiram