PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dithioerythritol, 1,4- | 6892-68-8 |
7.01
15.01
15.02
11.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C4.H10.O2.S2 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 154.26 | L |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.5 | 17 | 99 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.24 | 2.7 | 16 |
Technical Basis
A review of available sources did not identify exposure limits or acute toxicity data for 1,4-dithioerythritol. Instead, analysts evaluated acute toxicity (LD50) for an isomer, D-1,4-Dithiothreitol (CASRN: 3483-12-3) for TEEL development. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route toxicity data, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1,4-Dithiothreitol, CASRN: 3483-12-3; 500 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was an HHR=3, while the current TEEL-3 basis is a rat oral LD50 for an isomer of 1,4-dithioerythritol. The Rev. 29A and current TEEL-2/TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1,4-Dithiothreitol, CASRN: 3483-12-3; 500 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 was an HHR=3, while the current TEEL-3 basis is a rat oral LD50 for an isomer of 1,4-dithioerythritol. The Rev. 29A and current TEEL-2/TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Dithioerythritol
Chemical information, isomer D-1,4-Dithiothreitol, CASRN: 3483-12-3: https://pubchem.ncbi.nlm.nih.gov/compound/D-1_4-Dithiothreitol
Rat LD50. Retrieved From: https://chem.echa.europa.eu/100.020.427/dossier-view/48199cc9-5e92-462d-8a51-3b9442b6ecda/b1df6463-554b-4a61-8d7f-780d6e9cc871_7fe84819-a738-4986-8aa8-549f9fc6b224?searchText=3483-12-3