PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aminopropiophenone, 4- | 70-69-9 |
4.07
4.06
4.05
13.00
11.00
4.11
7.01
|
||||||||||
| Formula | Synonyms | |||||||||||
| C9H11NO | PROPIOPHENONE, 4^-AMINO-, 1-(4-AMINOPHENYL)-1-PROPANONE, 4'-AMINOPROPIOPHENONE, P-AMINOPROPIOPHENONE, PAPP, PARAMINOPROPIOPHENONE, PROPIOPHENONE, 4'-AMINO, USAF UCTL-1856 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 149.21 | S | 140 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.51 | 5.6 | 35 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.084 | 0.92 | 5.7 |
Technical Basis
A review of available sources identified LD50 toxicity data for multiple species (rat, mouse, dog) and routes (oral, intravenous, intraperitoneal), and a level of concern (LOC). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Two oral LD50 studies (rat and dog) were evaluated for the TEEL-3 basis. Although dog is a more preferred species, the rat data was from a more recent study (1983 versus 1944) and was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0056 g/m¬3)
• TEEL-3 = Rat oral LD50 (177 mg/kg)
This review generated TEEL values that are consistent with Rev. 29A*.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.0056 g/m¬3)
• TEEL-3 = Rat oral LD50 (177 mg/kg)
This review generated TEEL values that are consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/4_-Aminopropiophenone.
Rat oral LD50: Bulletin of Environmental Contamination and Toxicology., 30(122), 1983. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/4_-Aminopropiophenone.
Dog oral LD50 (50 mg/kg): Journal of Pharmacology and Experimental Therapeutics., 80(31), 1944. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/4_-Aminopropiophenone.
LOC: Retrieved from Appendix C (page C-8); https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf