PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Endosulfan | 115-29-7 | 2761 |
4.01
11.01
15.02
4.08
4.05
7.01
8.00
11.00
4.02
4.09
|
|||||||||
| Formula | Synonyms | |||||||||||
| C9H6Cl6O3S | ENDOSULFAN, 1,2,3,4,7,7-HEXACHLOROBICYCLO(2.2.1)HEPTEN-5,6-BIOXYMETHYLEN, 1,2,3,4,7,7-HEXACHLOROBICYCLO-[2.2.1]-HEPTEN-5,6-BISOXYMETHY, 1,2,3,4,7,7-HEXACHLOROBICYCLO[2.2.1]-2-HEPTENE-5,6-BISOXYMET, 1,2,3,4,7,7-HEXACHLOROBICYCLO[2.2.1]HEPTEN-5,6-BIOXYMETHYLEN, 1,4,5,6,7,7-HEXACHLORO-5-NORBORNENE-2,3-DIMETHANOL CYCLIC SU, 1,4,5,6,7,7-HEXACHLORO-5-NORBORNENE-2,3-DIMETHANOL, CYCLIC S, 1,4,5,6,7,7-HEXACHLORO-8,9,10-TRINORBORN-5-EN-2,3-YLENEDIMET, 2-DIMETHANOL, 5-NORBORNENE-2,3-DIMETHANOL, 1,4,5,6,7,7-HEXACHLORO-, CYCLIC, 6,7,8,9 10,10-HEXACHLORO-1,5,5A,6,9,9A-HEXAHYDRO-6,9-METHANO, 6,7,8,9,10,10-HEXACHLORO-1,5,5A,6,9,9A-HEXAHYDRO-6,9-METHANO, 6,7,8,9,10,10-HEXACHLORO-1,5,5A,6,9,9A-HEXAHYDRO-6,9-METHANO, 6,7,8,9,10-HEXACHLORO-1,5,5A,6,9,9A-HEXACHLORO-6,9-METHANO-, 6,9-METHANO-2,4,3-BENZODIOXATHIEPIN, 6,7,8,9,10,10-HEXACHLOR, ALPHA, BETA-1,2,3,4,7,7-HEXACHLOROBICYCLO)2.2.1)-2-HEPTENE-5, ALPHA, BETA-1,2,3,4,7,7-HEXACHLOROBICYCLO[2.2.1]-2-HEPTENE-5, AS 4314, BENZODIOXATHIEPIN-3-OXIDE, BENZOEPIN, BEOSIT, BIO 5,462, BIO 5,642, CHLORTHEPIN, CHLORTHIEPIN, CRISULFAN, CYCLODAN, DEVISULPHAN, ENDOCEL, ENDOSOL, ENDOSULFAN (DOT FRENCH), ENDOSULFAN 35EC, ENDOSULFANO (DOT SPANISH), ENDOSULPHAN, ENDOTAF, ENSURE, ENT 23,979, ENT 23979, FMC 5462, HEXACHLOROHEXAHYDROMETHANO 2,4,3-BENZODIOXATHIEPIN-3-OXIDE, HEXACHLOROHEXAHYDROMETHANO-2,4,3-BENZODIOXATHIEPIN-3-OXIDE, HILDAN, HOE 2,671, HOE 2671, INSECTOPHENE, KOP-THIODAN, MALIX, METHYLENE SULFITE, NCI C00566, NCI-C00566, NIA 5462, NIAGARA 5,462, NIAGARA 5462, NIAGRA 5462, OMS 570, PHASER, RCRA WASTE NUMBER P050, SD 4314, SULFUROUS ACID, CYCLIC ESTER WITH 1,4,5,6,7,7-HEXACHLORO-5-, SULFUROUS ACID, CYCLIC ESTER WITH 1,4,5,6,7,7-HEXACHLORO-5-N, THIFOR, THIMUL, THIODAN, THIODAN 35, THIODAN 35EC, THIODAN®, THIOFOR, THIOMUL, THIOMUL THIONEX, THIONEX, THIOSULFAN, THIOSULFAN TIONEL, THIOTOX, THIOTOX (INSECTICIDE), THIOTOX[INSECTICIDE], TIONEL, TIONEX, TIOVEL | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 406.93 | S | 106 | 20 | 1.745 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.20 | 0.80 | 3.5 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.012 | 0.048 | 0.21 |
Technical Basis
A review of available sources identified exposure limits (OEL-STELs, TWAs, LOC) and acute toxicity data (LC50, LD50, LDLo, TDLo) for numerous species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Human oral toxicity data was evaluated for TEEL development, however it was determined that LC50 data (inhalation) was more appropriate for TEEL development, even if a different species. As such, analysts selected a rat LC50, as the TEEL-3 basis and it was scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4), The LOC was selected as the TEEL-2. The OEL-STEL (Austria and Denmark) was selected as the TEEL-1.
• TEEL-1 = OEL-STEL (Austria and Denmark, 0.2 mg/m3)
• TEEL-2 = LOC (0.0008 gm/m3)
• TEEL-3 = Rat LC50 (80 mg/m3/4H)
This review generated TEEL-3 and TEEL-1 values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a human (male) oral LDLo; instead, analysts selected more statistically relevant acute inhalation toxicity data (rat LC50) as the TEEL-3 basis. The Rev. 29A and current TEEL-2 values, source, and methodology are consistent. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current TEEL-1 is an OEL-STEL (see note in Table 3.5).
• TEEL-1 = OEL-STEL (Austria and Denmark, 0.2 mg/m3)
• TEEL-2 = LOC (0.0008 gm/m3)
• TEEL-3 = Rat LC50 (80 mg/m3/4H)
This review generated TEEL-3 and TEEL-1 values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a human (male) oral LDLo; instead, analysts selected more statistically relevant acute inhalation toxicity data (rat LC50) as the TEEL-3 basis. The Rev. 29A and current TEEL-2 values, source, and methodology are consistent. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current TEEL-1 is an OEL-STEL (see note in Table 3.5).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Endosulfan
Rat LC50. Journal of Occupational Medicine., 9(35), 1967. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Endosulfan
Exposure limits: https://www.osha.gov/chemicaldata/139
OELs: https://ilv.ifa.dguv.de/limitvalues/25624
LOC. Appendix C, pg. C-4. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf