PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Endrin | 72-20-8 | 2761 |
15.01
11.01
15.02
4.08
4.05
7.01
7.00
11.00
4.09
4.06
|
|||||||||
| Formula | Synonyms | |||||||||||
| C12H8Cl6O | ENDRIN, (1A ALPHA, 2 BETA, 2A BETA, 3 ALPHA, 6 ALPHA, 6A BETA, 7 BET, 1,2,3,4, 10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHY, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY- 1,4,4A,5,6,7,8,8A-OCTAHY, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A- OCTAHY, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYD, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYD, 1,4:5,8-DIMETHANONAPHTHALENE, 1,2,3,4,10,10-HEXACHLORO-6,7-E, 1,4:5,8-DIMETHANONAPHTHALENE, 1,2,3,4,10,10-HEXACHLORO-6,7-E, 2,7:3,6-DIMETHANONAPHTH[2,3-B]OXIRENE, 3,4,5,6,9,9-HEXACHLOR, 2,7:3,6-DIMETHANONAPHTH[2,3-B]OXIRENE, 3,4,5,6,9,9-HEXACHLOR, 3,4,5,6,9,9,-HEXACHLORO-1A,2,2A,3,6,6A,7,7A-OCTAHYDRO-2,7:3,, 3,4,5,6,9,9-HEXACHLORO-1A,2,2A,3,6,6A,7,7A-OCTAHYDRO-2,7:3,6, 5,8-DIMETHANONAPHTHALENE, C00157, COMPOUND 269, EN 57, ENDREX, ENDRICAL, ENDRICOL, ENT 17,251, EXPERIMENTAL INSECTICIDE 269, HEXACHLOROEPOXYOCTAHYDRO-ENDO,ENDO- DIMETHANONAPHTHALENE, HEXACHLOROEPOXYOCTAHYDRO-ENDO,ENDO-DIMETHANONAPHTHALENE, HEXADRIN, HEXADRIN®, ISODRIN EPOXIDE, MENDRIN, NA 2761, NAPHTH(2,3-B)OXIRENE, NAPH[2,3-B]OXIRENE, NCI 01565, NCI-C00157, NENDRIN, OKTANEX, OMS 197, RCRA WASTE NUMBER P051, SD 3419, STARDRIN, STARDRIN 20 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 380.91 | S | 20 | 1.7 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.080 | 20 | 2000 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0051 | 1.3 | 130 |
Technical Basis
A review of available sources identified several acute toxicity data (LD50, LDLo) for various routes and species, and exposure limits (OEL-STELs, TWAs, IDLH, LOC). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. An oral LD50 of a preferred species, monkey, was evaluated for the TEEL-3 basis but resulted in a TEEL-3 < TEEL-2, when considering the preferred LOC as the TEEL-2; therefore, it was not selected. Multiple human (male & female) oral LDLo toxicity data were also evaluated but were not selected since they are lower priority data based on a single data point. Instead, the high priority IDLH (1990) was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The OEL-STEL (Poland) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = OEL-STEL (Poland, 0.08 mg/m3)
• PAC-2 = TEEL-2 = LOC (0.02 g/m3)
• PAC-3 = TEEL-3 = IDLH (1990)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and a PAC-1 inconsistent with Rev 29A. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 is an OEL-STEL for endrin. The Rev. 29A and current TEEL-3 and TEEL-2 use the same source and methodology.
• PAC-1 = TEEL-1 = OEL-STEL (Poland, 0.08 mg/m3)
• PAC-2 = TEEL-2 = LOC (0.02 g/m3)
• PAC-3 = TEEL-3 = IDLH (1990)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and a PAC-1 inconsistent with Rev 29A. The Rev. 29A TEEL-1 was derived from the TEEL-2, while the current TEEL-1 is an OEL-STEL for endrin. The Rev. 29A and current TEEL-3 and TEEL-2 use the same source and methodology.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Endrin.
IDLH (1990): https://www.cdc.gov/niosh/idlh/72208.html
LOC: Appendix C (page C-4); https://www.epa.gov/sites/default/files/2013-08/documents/technical_guidance_for_hazard_analysis.pdf
OEL-STEL: https://ilv.ifa.dguv.de/limitvalues/25671