PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epibatidine | 140111-52-0 |
8.00
7.01
4.08
4.05
|
||||||||||
| Formula | Synonyms | |||||||||||
| C11H13ClN2 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 208.69 | L |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0000090 | 0.000099 | 0.00059 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0000011 | 0.000012 | 0.000069 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for mouse and rat, with numerous routes (oral, intraperitoneal, intravenous). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.6.2, 3.6.3, 3.6.4, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species toxicity data, an intravenous rat LD50, was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat intravenous LD50 (1.5 ug/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-2 basis was a mouse intraperitoneal TDLo that was not found during current research; TEEL-1 and TEEL-3 values were derived from the TEEL-2. The current TEEL-3 basis is a rat intravenous LD50, a more preferred source (Table 3.1) and species (Section 3.6.4).
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat intravenous LD50 (1.5 ug/kg)
This review generated TEEL values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-2 basis was a mouse intraperitoneal TDLo that was not found during current research; TEEL-1 and TEEL-3 values were derived from the TEEL-2. The current TEEL-3 basis is a rat intravenous LD50, a more preferred source (Table 3.1) and species (Section 3.6.4).
References
Rat intravenous LD50 (1.5 ± 0.3 µg) for racemic mixture. Fitch RW, Snider BB, Zhou Q, Foxman BM, Pandya AA, Yakel JL, Olson TT, Al-Muhtasib N, Xiao Y, Welch KD, Panter KE. Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine. J Nat Prod. 2018 Apr 27;81(4):1029-1035. https://doi.org/10.1021%2Facs.jnatprod.8b00062
Sage W. Wiener, Lewis S. Nelson, Chapter 121 - Cholinergic Agent Attack (Nicotine, Epibatidine, and Anatoxin-a), Editor(s): Gregory R. Ciottone, Ciottone's Disaster Medicine (Second Edition), Elsevier, 2016, Pages 688-691. https://doi.org/10.1016/B978-0-323-28665-7.00121-7
https://comptox.epa.gov/dashboard/chemical/details/DTXSID00894067
https://pubchem.ncbi.nlm.nih.gov/compound/854023