PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Ergotamine tartrate 379-79-3 2811
7.00
3.08
3.05
7.11
3.07
5.00
5.10
Formula Synonyms
C66.H70.N10.O10.C4.H6.O6 ERGOTAMINE TARTRATE, 8H-OXAZOLO[3,2-A]PYRROLO[2,1-C]PYRAZINE, ERGOTAMAN-3^,6',18-, COMPONENT OF CAFERGOT, ERGAM, ERGATE, ERGOMAR, ERGOTAMAN-3',6',18-TRIONE, 12'-HYDROXY-2'-METHYL-5'-(PHENYLM, ERGOTAMAN-3',6',18-TRIONE, 12'-HYDROXY-2'-METHYL-5'-(PHENYLM, ERGOTAMINE BITARTRATE, ERGOTAMINE, TARTRATE (2:1) (SALT), ERGOTAMINE, TARTRATE(2:1)(SALT), ETIN, EXMIGRA, FEMERGIN, GOTAMINE, GOTAMINE TARTRATE, GYNERGEN, INDOLO[4,3-FG]QUINOLINE, ERGOTAMAN-3',6',18-TRIONE DERIV., LINGRAINE, LINGRAN, NEO-ERGOTIN, RIGETAMIN, SECAGYN, SECUPAN, TARTRATE
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
1313.56 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.91 10 32
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.017 0.19 0.60
Technical Basis
A review of available sources identified a LOC and several acute toxicity data (LD50, LDLo, TDLo) for various routes and species. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred data, a rat intravenous LD50, was selected as the TEEL-3 basis. The high priority LOC was selected as the TEEL-2. The TEEL-1 was derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.01 g/m3)
• PAC-3 = TEEL-3 = Rat intravenous LD50 (80 mg/kg)
This review generated PAC values that are consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Ergotamine-Tartrate.
LOC: Appendix C (page C-4); https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
Rat intravenous LD50: Muenchener Medicinische Wochenschrift., 75(736), 1928. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Ergotamine-Tartrate.
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.