A review of available sources did not identify exposure limits or acute toxicity data for this chemical. Reported GHS health hazard ratings (H315 and H319, Category 2; H335, respiratory Category 3) indicate a mid-level health hazard, approximately equivalent to an HHR=2. In additional, analysts evaluated available toxicity (LD50) for a similar chemical, titanium tetraisopropanolate (CASRN: 546-68-9), for TEEL development (Section 3.4.6). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts selected the titanium tetraisopropanolate rat oral LD50 as the TEEL-3 basis (Section 3.4.6); this value was reported in units of uL/kg therefore it was converted using the density (0.9711 g/mL at 20°C). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat Oral LD50 (titanium tetraisopropanolate, CASRN: 546-68-9; 7460 µL/kg converted to 7244 mg/kg using density of 0.9711 at 20 °C)
This review generated PAC values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA for particles not otherwise specified (Section 3.5.2), from which the TEEL-2 and TEEL-3 were derived (Table 3.5). The current TEEL-3 is a rat oral LD50 for a similar chemical (Section 3.4.6), from which the TEEL-2 and TEEL-1 were derived (Table 3.5).