PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethion | 563-12-2 | 2783 |
6.00
4.01
11.01
4.08
4.05
7.01
7.00
11.00
4.07
3.08
|
|||||||||
| Formula | Synonyms | |||||||||||
| C9.H22.O4.P2.S4 | ETHION, AC 3422, BIS(S-(DIETHOXYPHOSPHINOTHIOYL)MERCAPTO)METHANE, BLADAN, DIETHION, EMBATHION, ENT 24,105, ETHANOX, ETHIOL, ETHIOL 100, ÉTHION (DOT FRENCH), ETHODAN, ETHOPAZ, ETHYL METHYLENE PHOSPHORODITHIOATE, ETHYL METHYLENE PHOSPHORODITHIOATE ([(ETO)2P(S)S]2CH2), ETION (DOT SPANISH), FMC-1240, FOSFATOX E, FOSFONO 50, HYLEMAX, HYLEMOX, ITOPAZ, KWIT, NIA 12 40, NIA 1240, NIAGARA 1240, NIALATE, O, O^, O'-TETRAETHYL S, O,O,O',O'- TETRAETHYL S,S'-METHYLENE DI(PHOSPHORODITHIOATE), O,O,O',O'-TETRAETHYL S,S'- METHYLENEBISPHOSPHORDITHIOATE, O,O,O',O'-TETRAETHYL S,S'-METHYLENE BIS(PHOSPHORODITHIOATE), O,O,O',O'-TETRAETHYL S,S'-METHYLENEBISPHOS- PHORODITHIOATE, O,O,O,O-TETRAETHYL S,S'-METHYLENEBIS(DITHIOPHOSPHATE), PHOSPHORODITHIOIC ACID, O,O-DIETHYL ESTER, S,S-DIESTER WITH, PHOSPHORODITHIOIC ACID, S,S'-METHYLENE O,O,O',O'-TETRAETHYL, PHOSPHOTOX E, RHODIACIDE, RHODOCIDE, RODOCID, RODOCIDE, RP 8167, S'-METHYLENE DI(PHOSPHORODITHIOATE), S,S'-METHYLENE O,O,O',O'-TETRAETHYL PHOSPHORODITHIOATE, SOPRATHION, TETRAETHYL S,S'-METHYLENE BIS(PHOSPHOROTHIOLOTHIONATE), VEGFRU FOSMITE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 384.49 | L | -13 | 1.31 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.15 | 0.43 | 2.6 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0095 | 0.027 | 0.17 |
Technical Basis
A review of available sources identified exposure limits (LOC, STEL, TWAs) and acute toxicity data (LC50, LD50, TDLo) for numerous species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts could not identify the duration of the rat LC50, therefore it was not selected for TEEL development. Instead, analysts selected a rat oral LD50 as the TEEL-3 basis. The LOC was evaluated, however this resulted in a TEEL-2 > TEEL-3. The human TDLo was evaluated; however, it did not report toxicity endpoints appropriate for TEEL development; instead, the TEEL-2 was derived according to Table 3.5. The report OEL-STEL was evaluated (Spain, 30 ppm) but it resulted in a TEEL-1 > TEEL-2. Instead, the lowest reported OEL-TWA (Belgium, Canada, Ireland, Spain) was selected as the TEEL-1 basis.
• PAC-1 = TEEL-1 = OEL-TWA (0.05 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (13 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 4-hour rat LC50 not identified during this review; instead, the current TEEL-3 is a rat oral LD50. The Rev. 29A TEEL-2 was the LOC, which was evaluated in this review but not selected due because it resulted in a TEEL-2 > TEEL-3. Instead, the TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the LOC, while the current TEEL-1 basis is an OEL-TWA.
• PAC-1 = TEEL-1 = OEL-TWA (0.05 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (13 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 4-hour rat LC50 not identified during this review; instead, the current TEEL-3 is a rat oral LD50. The Rev. 29A TEEL-2 was the LOC, which was evaluated in this review but not selected due because it resulted in a TEEL-2 > TEEL-3. Instead, the TEEL-2 was derived from the TEEL-3 (Table 3.5). The Rev. 29A TEEL-1 was derived from the LOC, while the current TEEL-1 basis is an OEL-TWA.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Ethion.
Rat LD50. Pharmaceutical Journal., 185(361), 1960. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Ethion
OELs: https://ilv.ifa.dguv.de/limitvalues/26482