PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Ethyl acetoacetate 141-97-9 1993
14.01
16.02
11.01
18.00
Formula Synonyms
C6.H10.O3 ETHYL ACETOACETATE, 1-ETHOXYBUTANE-1,3-DIONE, 3-OXOBUTANOIC ACID ETHYL ESTER, ACETOACETIC ACID, ETHYL ESTER, ACETOACETIC ESTER, DIACETIC ETHER, EAA, ETHYL 3-KETOBUTYRATE, ETHYL 3-OXOBUTANOATE, ETHYL 3-OXOBUTYRATE, ETHYL ACETONECARBOXYLATE, ETHYL ACETYLACETATE
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
130.16 L 180.8 0.78 25 1.0282 @ 20°C 14000
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
12 130 790
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
2.3 24 150
Technical Basis
A review of available sources identified acute toxicity data (LD50, LC50) for various species and routes, and exposure limits (OEL-STEL & OEL-TWA (Romania)). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although there was a preferred inhalation exposure on PubChem, a 4-hour rat LC50, it could not be used since the source was not listed. Instead, a rat oral LD50 was selected as the TEEL-3 basis. The OEL-STEL and OEL-TWA were evaluated for the TEEL-1 basis but resulted in values of 200 mg/m3 and 300 mg/m3 respectively, that were high relative to the TEEL-3 value based on the rat toxicity data; therefore, they were not selected for the TEEL-1 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (3980 mg/kg)
This review generated PAC values consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Ethyl-acetoacetate.
Rat oral LD50: Journal of Industrial Hygiene and Toxicology., 31(60), 1949. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Ethyl-acetoacetate.
OEL-STEL & OEL-TWA: https://ilv.ifa.dguv.de/limitvalues/26828
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.