PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Amiton oxalate 3734-97-2
6.00
4.01
4.05
7.01
7.00
4.07
3.05
7.11
7.10
3.02
Formula Synonyms
C12H26NO7PS AMITON OXALATE, CHIPMAN 6199, CHIPMAN R-6,199, CITRAM, ENT 20,993, HYDROGEN OXALATE OF AMITON, O,O-DIETHYL S-(2-DIETHYLAMINO)ETHYL PHOSPHOROTHIOATE HYDROGE, O,O-DIETHYL S-(2-ETHYL-N,N-DIETHYLAMINO) PHOSPHOROTHIOATE HY, O,O-DIETHYL S-(BETA-DIETHYLAMINO)ETHYL PHOSPHOROTHIOLATE HYD, O,O-DIETHYL-S-(2-DIETHYLAMINO) ETHYLPHOSPHOROTHIOATE HYDROGE, PHOSPHOROTHIOIC ACID, S-(2-DIETHYLAMINO)ETHYL) O,O-DIETHYL E, PHOSPHOROTHIOIC ACID, S-[2-(DIETHYLAMINO)ETHYL] O,O-DIETHYL, PHOSPHOROTHIOIC ACID, S-[2-(DIETHYLAMINO)ETHYL] O,O-DIETHYL, PHOSPHOROTHIOIC ACID, S-[2-(DIETHYLAMINO)ETHYL] O,O-DIETHYL, S-(2-DIETHYLAMINOETHYL) O,O-DIETHYL PHOSPHOROTHIOATE HYDROGE, S-(2-DIETHYLAMINOETHYL) O,O-DIETHYLPHOSPHOROTHIOATE HYDROGEN, TETRAM, TETRAM 75, TETRAM MONOOXALATE, TETRAM, ACID OXALATE
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
359.42 S 0.01 80
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
0.0090 0.099 0.59
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.00061 0.0067 0.040
Technical Basis
A review of available sources identified a LOC and rat and mouse acute toxicity data (LD50) for several routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. A rat oral LD50 was selected as the TEEL-3 source. The LOC was evaluated; however, it resulted in a TEEL-2 > TEEL-3. Acute toxicities indicate that a more conservative approach is appropriate; as such, TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (3 mg/kg)
This review generated TEEL values that are consistent with Rev. 29A*.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Amiton-oxalate
LOC. Appendix C, pg. C-2. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
Rat oral LD50 (3mg/kg): Pesticide Index, Frear, E.H., ed., State College, PA, College Science Pub., 1969, 4(162), 1969 Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 7, 1966. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Amiton-oxalate
Rat skin LD50 (2mg/kg): Toxicology and Applied Pharmacology., 2(1), 1960 [PMID:14445369]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Amiton-oxalate
Mouse intraperitoneal LD50 (2mg/kg): Pharmacological Reviews., 11(636), 1959. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Amiton-oxalate
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.