PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethyl chloroacetate | 105-39-5 | 1181 |
14.01
8.00
4.11
7.00
11.00
11.01
15.02
|
|||||||||
| Formula | Synonyms | |||||||||||
| C4.H7.Cl.O2 | ETHYL CHLOROACETATE, (ETHOXYCARBONYL)METHYL CHLORIDE, 2-CHLOROACETIC ACID ETHYL ESTER, CHLORACÉTATE D^ÉTHYLE (DOT FRENCH), CHLOROACETIC ACID ETHYL ESTER, CHLOROACETIC ACID, ETHYL ESTER, CLOROACETATO DE ETILO (DOT SPANISH), ETHYL 2-CHLOROACETATE, ETHYL ALPHA-CHLOROACETATE, ETHYL CHLORACETATE, ETHYL CHLOROETHANOATE, ETHYL MONOCHLORACETATE, ETHYL MONOCHLOROACETATE, MONOCHLORETHANOIC ACID, ETHYL ESTER | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 122.56 | L | -27 | 144 | 10 | 37.5 | 1.145 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 2.6 | 28 | 170 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.52 | 5.6 | 34 |
Technical Basis
A review of available sources identified the following toxicity exposures: LC50 and several LD50 (mouse, rat) toxicity data for oral and intraperitoneal routes. Data sources were selected according to the hierarchy listed in Table 3.1. The toxicity data was evaluated using factors in Tables 3.2, 3.3, and 3.4 and scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4.) The LC50 was selected as the TEEL-3 basis because it was the most preferred source. TEEL-1 and TEEL-2 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from rat 4-hr LC50 (3330 µL/m3, Density = 1.15)
This review generated TEEL values less conservative than those in Rev. 29A. In Rev. 29A, a rat oral LD50 was the reported TEEL-3 basis. In the current review, a LC50 was selected instead, as it is the most preferred toxicity route (Table 3.1).
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from rat 4-hr LC50 (3330 µL/m3, Density = 1.15)
This review generated TEEL values less conservative than those in Rev. 29A. In Rev. 29A, a rat oral LD50 was the reported TEEL-3 basis. In the current review, a LC50 was selected instead, as it is the most preferred toxicity route (Table 3.1).
References
https://cameochemicals.noaa.gov/chemical/675
BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals., 5(71), 1993; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 7751, Ethyl chloroacetate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Ethyl-chloroacetate
U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge, National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 7751, Ethyl chloroacetate. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Ethyl-chloroacetate.