PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethylenediaminetetraacetic acid, disodium salt | 139-33-3 |
4.05
7.01
4.07
3.09
3.10
3.01
5.00
5.10
|
||||||||||
| Formula | Synonyms | |||||||||||
| C10H14N2Na2O8 | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 336.24 | S | 25 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 6.0 | 66 | 400 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.44 | 4.8 | 29 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The lowest reported rat oral LD50 was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2000 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50; the current TEEL-3 basis is also a rat oral LD50, however the current review identified a lower dose. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (2000 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50; the current TEEL-3 basis is also a rat oral LD50, however the current review identified a lower dose. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/8759
Rat LD50. Federation Proceedings, Federation of American Societies for Experimental Biology., 27(465), 1968. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/8759
Additional acute toxicity data: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8013#section=Non-Human-Toxicity-Values-%28Complete%29&fullscreen=true