PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Formaldehyde cyanohydrin; (Hydroxyacetonitrile; Glycolonitrile) 107-16-4 2810
17.00
18.00
15.01
4.01
4.08
4.05
7.01
8.00
7.00
4.07
Formula Synonyms
C2.H3.N.O FORMALDEHYDE CYANOHYDRIN, 2-HYDROXYACETONITRILE, 2-HYDROXYMETHYLNITRILE, ACETONITRILE, HYDROXY-, ALPHA- HYDROXYACETONITRILE, ALPHA-HYDROXYMETHYLCYANIDE, CYANOMETHANOL, CYANOMETHYL ALCOHOL, FORMALDEHYDE, CYANOHYDRIN, GLYCOLIC NITRILE, GLYCOLONITRILE, GLYCONITRILE, HYDROXYACETONITRILE, HYDROXYMETHYL CYANIDE, HYDROXYMETHYLNITRILE, METHYLENE CYANOHYDRIN, USAF A-8565
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
57.06 L 183 1.8 25 1.1
PAC Values
PAC Values (Original Units: ppm)
PAC-1 PAC-2 PAC-3
0.24 2.6 11
Converted PAC Values (mg/m3)
PAC-1 PAC-2 PAC-3
0.56 6.1 26
Technical Basis
A review of available sources identified acute toxicity data (LCLo and LD50) for various species and routes, and exposure limits (LOC, REL-C). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Two rat LCLo data were evaluated for the TEEL-3 basis (250 ppm/4H and 27 ppm/8H). When considering the preferred LOC as the TEEL-2 basis, the more conservative dose was not selected since it resulted in TEEL-3 < TEEL-2. Instead, the less conservative 4-hour dose (250 ppm) was selected as the TEEL-3 basis. The LOC was selected as TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.006 g/m3)
• PAC-3 = TEEL-3 = Rat LCLo (250 ppm/4H)
This review generated PAC values that are consistent with Rev. 29A*.
References
Chemical Information: https://pubchem.ncbi.nlm.nih.gov/compound/Glycolonitrile
Rat LCLo (250 ppm/4H): Retrieved from https://stacks.cdc.gov/view/cdc/19427 ; Table III-3, page 71 https://recherche.chemikalieninfo.de/public/stoff/23328?dv=18&sv=
Rat LCLo (27 ppm/8H): Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, -(290), 1969. Retrieved from National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 7857, Glycolonitrile. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Glycolonitrile
LOC: Appendix C (page C-5); https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.