PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Formothion | 2540-82-1 |
6.00
4.01
11.01
15.02
4.08
4.05
7.01
8.00
7.00
11.00
|
||||||||||
| Formula | Synonyms | |||||||||||
| C6H12NO4PS2 | FORMOTHION, AFLIX, ANTHIO, ANTHIO 25, ANTHIO 33, ANTIO, CP 53926, ENT 27,257, ENT 27257, FORMITHION, J-38, N-FORMYL-N-METHYLCARBAMOYLMETHYL O,O-DIMETHYL PHOSPHORODI- T, O,O-DIMETHYL DITHIOPHOSPHORYLACETIC ACID N-METHYL-N-FORMYLAM, O,O-DIMETHYL PHOSPHORODITHIOATE N-FORMYL-2-MERCAPTO-N-METHYL, O,O-DIMETHYL S-(N-FORMYL-N-METHYLCARBAMOYLMETHYL) PHOSPHOROD, O,O-DIMETHYL S-(N-METHYL-N-FORMYLCARBAMOYLMETHYL) PHOSPHOROD, OMS-968, P 1, PHOSPHORODITHIOIC ACID, O,O-DIMETHYL ESTER, N-FORMYL-2-MERCA, PHOSPHORODITHIOIC ACID, O,O-DIMETHYL ESTER, S-ESTER WITH N-F, PHOSPHORODITHIOIC ACID, S-(2-(FORMYLMETHYLAMINO)-2-OXOETHYL), S 6900, S-(2-(FORMYLMETHYLAMINO)-2-OXOETHYL) O,O-DIMETHYL PHOSPHOROD, S-(N-FORMYL-N-METHYLCARBAMOYLMETHYL) DIMETHYL PHOSPHOROTHIOL, S-(N-FORMYL-N-METHYLCARBAMOYLMETHYL) O,O-DIMETHYL PHOSPHOROD, SAN 244 I, SAN 6913 I, SAN 7107 I, TOPROSE, VEL 4284 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 257.27 | L | 25.5 | 0.0000085 | 30 | 1.361 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.025 | 0.27 | 200 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.0024 | 0.026 | 19 |
Technical Basis
A review of available sources identified acute toxicity data (LC50, LD50) for various species and routes, and an exposure limit (LOC). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled down to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred route and species data, a 4-hour rat LC50, was selected as the TEEL-3 basis. The LOC was selected as the TEEL-2. The TEEL-1 value was derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.00027 g/m3)
• PAC-3 = TEEL-3 = Rat LC50 (4500 mg/m3/4H)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a 4-hour rat LC50; however, that dose was not found in the current review. Instead, a rat LC50 of a less conservative dose was found and selected as the current TEEL-3 basis. The Rev. 29A TEEL-2 was derived from the TEEL-3 (Table 3.5), while the current TEEL-2 is the high priority LOC. The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in TEEL-2.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = LOC (0.00027 g/m3)
• PAC-3 = TEEL-3 = Rat LC50 (4500 mg/m3/4H)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a 4-hour rat LC50; however, that dose was not found in the current review. Instead, a rat LC50 of a less conservative dose was found and selected as the current TEEL-3 basis. The Rev. 29A TEEL-2 was derived from the TEEL-3 (Table 3.5), while the current TEEL-2 is the high priority LOC. The Rev. 29A and current TEEL-1 use the same methodology, with differences due to the change in TEEL-2.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Formothion.
LOC: Appendix C (page C-5); https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf
Rat LC50: Pesticide Manual., 9(440), 1991 Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Formothion.