PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heptachlor | 76-44-8 | 2761 |
2.00
3.10
4.05
7.01
4.10
5.10
11.00
3.09
4.09
|
|||||||||
| Formula | Synonyms | |||||||||||
| C10H5Cl7 | HEPTACHLOR, 1, 1(3A),4,5,6,7,8,8-HEPTACHLORO-3A(1),4,7,7A-TETRAHYDRO-4,7-ME, 1,4,5,6,7,10,10-HEPTACHLORO-4,7,8,9-TETRAHYDRO-4,7-ENDOMETHY, 1,4,5,6,7,10,10-HEPTACHLORO-4,7,8,9-TETRAHYDRO-4,7-METHYLENE, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7,7A-TETRAHYDRO-4,7-METHYLE, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-ENDOMETHA, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANO-1, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANOIN, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANOL-, 1,4,5,6,7,8,8A-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANOI, 1,4,5,6,7,8,8A-HEPTACHLORODICYCLOPENTADIENE, 3,4,5,6,7,8,8-HEPTACHLORODICYCLOPENTADIENE, 3,4,5,6,7,8,8A-HEPTACHLORODICYCLOPENTADIENE, 3-CHLOROCHLORDENE, 4, 4,7-METHANOINDENE, 1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRA, 5, 6, 7, 7-METHANOINDENE, 7A-TETRAHYDRO-4, 8, 8-HEPTACHLORO-3A, AAHEPTA, AGROCERES, ARBINEX 30TN, DICYCLOPENTADIENE, 3,4,5,6,7,8,8A-HEPTACHLORO-, DRINOX, DRINOX H-34, E 3314, E3314, ENT 15,152, GPKH, H, H-34, H-60, HEPTA, HEPTACHLORANE, HEPTAGRAN, HEPTAMUL, HEPTOX, NCI-C00180, RCRA WASTE NUMBER P059, RHODIACHLOR, VELSICOL, VELSICOL 104, VELSICOL HEPTACHLOR | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 373.32 | S | 95.5 | 25 | 1.57 @ 9°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.40 | 14 | 700 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.026 | 0.92 | 46 |
Technical Basis
A review of available sources identified several acute toxicity data (LD50, LDLo, LCLo, TDLo) for various routes and species, and exposure limits (IDLH, TWAs, OEL-STELs, MAK-STEL). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The IDLH (1990) was selected as the TEEL-3 basis. The TDLo of the most preferred species and route, a rat oral TDLo, was selected as the TEEL-2 basis. The MAK-STEL was selected as the TEEL-1.
• PAC-1 = TEEL-1 = MAK-STEL (0.4 mg/m3; inhalable fraction)
• PAC-2 = TEEL-2 = Rat oral TDLo (60 mg/kg)
• PAC-3 = TEEL-3 = IDLH (1990, 700 mg/m3)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current recommendation is a higher priority MAK-STEL (Table 3.1). The Rev. 29A and current TEEL-2 and TEEL-3 values, source, and methodology are consistent.
• PAC-1 = TEEL-1 = MAK-STEL (0.4 mg/m3; inhalable fraction)
• PAC-2 = TEEL-2 = Rat oral TDLo (60 mg/kg)
• PAC-3 = TEEL-3 = IDLH (1990, 700 mg/m3)
This review generated PAC-3 and PAC-2 values consistent with Rev. 29A and a PAC-1 value inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA, while the current recommendation is a higher priority MAK-STEL (Table 3.1). The Rev. 29A and current TEEL-2 and TEEL-3 values, source, and methodology are consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Heptachlor.
IDLH: https://www.cdc.gov/niosh/idlh/76448.html
MAK-STEL: https://ilv.ifa.dguv.de/limitvalues/30751
Rat oral TDLo: https://www.cdc.gov/niosh-rtecs/PCAAE60.html