PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hexachloroacetone | 116-16-5 | 2661 |
15.01
11.01
15.02
4.05
7.01
8.00
7.00
11.00
7.11
10.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3.Cl6.O | HEXACHLOROACETONE, 1,1,1,3,3,3-HEXACHLORO-2-PROPANONE, 1,1,1,3,3,3-HEXACHLOROPROPANONE, 2-PROPANONE, HEXACHLORO-, BIS(TRICHLOROMETHYL) KETONE, HCA, HEXACHLORACÉTONE (DOT FRENCH), HEXACHLORO-2-PROPANONE, HEXACHLOROPROPANONE, HEXACLOROACETONA (DOT SPANISH), PERCHLOROACETONE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 264.73 | L | -2 | 202.2 | 0.376 | 20 | 1.74 @ 12°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.14 | 3.0 | 18 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.5 | 32 | 190 |
Technical Basis
A review of available sources identified exposure limits (OEL-TWA) and acute toxicity data (LC50, LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The most preferred species and route, a rat LC50, was selected as the TEEL-3 basis. The TEEL-2 was derived according to Table 3.5. The OEL-TWA (Latvia) was selected as the TEEL-1 basis.
• TEEL-1 = OEL-TWA (Latvia, 0.5 mg/m3) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (360 ppm/6H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 3-hour rat LC50 not found during the review; instead, analysts selected a 4-hour rat LC50. The Rev. 29A TEEL-2 basis was a TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2; instead, the TEEL-1 basis is an exposure limit (OEL-TWA).
• TEEL-1 = OEL-TWA (Latvia, 0.5 mg/m3) x 3
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LC50 (360 ppm/6H)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a 3-hour rat LC50 not found during the review; instead, analysts selected a 4-hour rat LC50. The Rev. 29A TEEL-2 basis was a TDLo not found during the current review; instead, the TEEL-2 was derived from the TEEL-3. The Rev. 29A TEEL-1 was derived from the TEEL-2; instead, the TEEL-1 basis is an exposure limit (OEL-TWA).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Hexachloroacetone.
Rat LC50. Toxicology and Applied Pharmacology., 7(592), 1965 [PMID:5839393]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Hexachloroacetone.
OEL-TWA, Latvia. https://ilv.ifa.dguv.de/limitvalues/31290