PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hexamethylphosphoramide | 680-31-9 |
15.01
11.01
15.02
4.05
7.01
8.00
7.00
11.00
4.09
4.06
|
||||||||||
| Formula | Synonyms | |||||||||||
| C6H18N3OP | HEXAMETHYLPHOSPHORAMIDE, HEXAMETHYLPHOSPHOROTRIAMIDE, HEXAMETHYLPHOSPHOTRIAMIDE, HEXAMETHYLTRIAMIDOPHOSPHATE, HMPA, HMPT, HMPTA, HPT, N,N^,N''-HEXAMETHYLPHOSPHORAMIDE, N,N,N,N,N,N-HEXAMETHYLPHOSPHORIC TRIAMIDE, PHOSPHORIC ACID HEXAMETHYLTRIAMIDE, PHOSPHORIC HEXAMETHYLTRIAMIDE, PHOSPHORIC TRIS(DIMETHYLAMIDE), PHOSPHORYL HEXAMETHYLTRIAMIDE, TRIS(DIMETHYLAMINO)PHOSPHINE OXIDE, TRIS(DIMETHYLAMINO)PHOSPHORUS OXIDE, EASTMAN INHIBITOR HPT, ENT 50,882, ENT 50882, HEMPA, HEXAMETAPOL, HEXAMETHYL PHOSPHORAMIDE, HEXAMETHYLORTHOPHOSPHORIC TRIAMIDE, HEXAMETHYLPHOSPHORIC ACID TRIAMIDE, HEXAMETHYLPHOSPHORIC TRIAMIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 179.2 | L | 7.2 | 232.5 | 0.03 | 25 | 1.03 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.9 | 21 | 130 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.26 | 2.9 | 18 |
Technical Basis
A review of available sources identified the following: LD50 (guinea pig, rat) and LCLo toxicity data. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The LCLo was scaled to 60-minute equivalent using the ten Berge equation (Section 3.3.4). Of the available sources, the rat 4-hr LC¬50 was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 =TEEL-3/6
• TEEL-3 = Rat 4-hr LCLo (2920 mg/m3)
This review generated TEEL-3 values consistent with Rev. 29A. The current TEEL-2 and TEEL-1 recommendations are slightly more conservative than Rev. 29A due to a different TEEL-2 basis, a rat oral TDLo, which was not identified in research.
• TEEL-1 = TEEL-2/11
• TEEL-2 =TEEL-3/6
• TEEL-3 = Rat 4-hr LCLo (2920 mg/m3)
This review generated TEEL-3 values consistent with Rev. 29A. The current TEEL-2 and TEEL-1 recommendations are slightly more conservative than Rev. 29A due to a different TEEL-2 basis, a rat oral TDLo, which was not identified in research.
References
https://cameochemicals.noaa.gov/chemical/16116
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information., OTS0571242. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Hexamethylphosphoramide
Principles of Insect Chemosterilization, Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968, 315,1968. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Hexamethylphosphoramide
Nature, 211,146,1966. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Hexamethylphosphoramide