A review of the limited sources did not identify exposure or toxicity data for 2,6,10,15,19,23-hexamethyltetracosane. Its GHS classification was reviewed; a summary of GHS hazard statements indicates low-to-mid level hazards (GHS categories 2A, and 3) for eye, dermal, and respiratory exposure, indicating at a minimum an HHR=1. Considering the GHS Hazard Statements for this compound, “May cause respiratory irritation” and,” causes skin irritation”, it was determined to be a mid-level hazard, equivalent to an HHR =2. The toxicity for a similar compound, squalene (CASRN: 111-02-4) was also evaluated and identified the following: acute toxicity data for mouse in the form of oral and intravenous exposures. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Considering the evaluated sources, an HHR=2 was selected as the TEEL-3 basis (Section 3.4.5). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = HHR=2
This review generated TEEL values that were consistent with Rev. 29A.