PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Hydroxyethyl)-1-piperazineethanesulfonic acid, 4-(2- 7365-45-9
4.00
3.00
Formula Synonyms
C6.H18.N2.O4.S
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
238.24 S
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
30 330 2000
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
3.1 34 210
Technical Basis
A review of available sources did not identify exposure limits or acute toxicity data for 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid. GHS data was evaluated, but the chemical does not meet GHS hazard criteria for 95.6% of all reports and is therefore not classified. Additionally, toxicity data indicates that no rats died when exposed to a dose of >2000 mg/kg. Considering this, the PNOS TLV-TWA was selected as the TEEL-1 basis (PNOS, Section 3.5.2). TEEL-3 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TLV-TWA (PNOS, 10 mg/m3) x 3
• PAC-2 = TEEL-2 = TEEL-1 x 11
• PAC-3 = TEEL-3 = TEEL-2 x 6
This review generated PAC consistent with Rev. 29A*.
References
Chemical information and GHS classification: https://pubchem.ncbi.nlm.nih.gov/compound/hepes.
Rat oral LD50: https://chem.echa.europa.eu/100.028.098/dossier-view/c6218b81-9b15-4395-913a-a0ddec05b329/b59470d2-3dec-4d6c-9870-f96d8518b3e3_44e38bfa-fa5f-4c2f-80d5-7bcc6e65c300
Search Again
PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.