Technical Basis
A review of available sources identified a rat acute toxicity data (LD50, LC50) for inhalation and oral routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Although there was a preferred inhalation data, rat LC50, the duration was not listed; therefore, it was not selected for TEEL development. The rat oral LD50 was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1749 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL sources and methodology remain consistent; as such, differences in values may be due to rounding.