PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Isobutylamine | 78-81-9 | 1214 |
14.02
14.01
7.01
4.05
11.00
11.01
7.00
4.08
4.01
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C4H11N | ISOBUTYLAMINE, 1-AMINO-2-METHYLPROPANE, 2-METHYL-1-AMINOPROPANE, 2-METHYL-1-PROPANAMINE, 2-METHYLPROPANAMINE, 2-METHYLPROPYLAMINE, 3-METHYL-2-PROPYLAMINE, ISO-BUTYLAMINE, ISOBUTILAMINA (DOT SPANISH), ISOBUTYLAMINE (DOT FRENCH), ISOBUTYLAMINE (DOT), MONOISOBUTYLAMINE, VALAMINE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 73.16 | L | -85.5 | 68.6 | 138 | 25 | 0.731 @ 20°C | 34000 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 12.2 | 15 | 44 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 4.1 | 5.0 | 15 |
Technical Basis
A review of available sources identified rat oral LD50 toxicity data and exposure limits (MAK-STEL, MAK-C, OEL-STELs, OEL-TWAs). Data sources were selected according to the hierarchy listed in Table 3.1. The rat oral LD50 was selected as the TEEL-3 basis and was evaluated using factors in Tables 3.2, 3.3, and 3.4. The MAK-C (Germany DFG, Ceiling) was selected as the TEEL-2. The MAK-STEL (Germany DFG, 15-minute average value) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = MAK-STEL
• PAC-2 = TEEL-2 = MAK-C
• PAC-3 = TEEL-3 = Rat oral LD50 (224 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are consistent, a rat oral LD50; the minor difference may be due to rounding. The Rev. 29A and current TEEL-2 basis are consistent, a MAK-C; however, the recommended basis is a more conservative MAK-C value. In Rev. 29A, the TEEL-1 basis was the MAK-TWA, while the current basis is a higher priority MAK-STEL (Table 3.1).
• PAC-1 = TEEL-1 = MAK-STEL
• PAC-2 = TEEL-2 = MAK-C
• PAC-3 = TEEL-3 = Rat oral LD50 (224 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A and current TEEL-3 basis are consistent, a rat oral LD50; the minor difference may be due to rounding. The Rev. 29A and current TEEL-2 basis are consistent, a MAK-C; however, the recommended basis is a more conservative MAK-C value. In Rev. 29A, the TEEL-1 basis was the MAK-TWA, while the current basis is a higher priority MAK-STEL (Table 3.1).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Isobutylamine.
Rat oral LD50: Toxicology and Applied Pharmacology., 63(150), 1982 [PMID:7071869]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Isobutylamine.
MAK-STEL and C: https://ilv.ifa.dguv.de/limitvalues/8328