PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lactonitrile | 78-97-7 | 2811 |
15.01
14.02
7.01
7.00
11.00
4.05
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3H5NO | LACTONITRILE, (.+-.)-2-HYDROXYPROPANENITRILE, (.+-.)-2-HYDROXYPROPIONITRILE, 2-HYDROXYPROPANENITRILE, 2-HYDROXYPROPANOIC ACID, NITRILE, 2-HYDROXYPROPIONITRILE, ACETALDEHYDE CYANOHYDRIN, ACETALDEHYDE, CYANOHYDRIN, ACETOCYANOHYDRIN, ALPHA-HYDROXYPROPIONITRILE, D-LACTONITRILE, ETHYLIDENE CYANOHYDRIN, ETHYLIDENECYANOHYDRIN, LACTONITRILE SOLUTION (80% OR LESS), PROPANENITRILE, 2-HYDROXY-, PROPANOIC ACID, 2-HYDROXY-, NITRILE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 71.09 | L | -40 | 221 | 0.119 | 25 | 0.9834 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.081 | 0.89 | 5.4 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.24 | 2.6 | 16 |
Technical Basis
A review of available sources identified LD50, LCLo, and LDLo acute toxicity data for various species (rat, mouse, rabbit, frog) and exposure routes (oral, dermal, inhalation, intraperitoneal). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred data type, a rat LCLo, was selected as the TEEL-3 basis and scaled to a 60-minute equivalent using the ten Berge equation (Section 3.3.4). TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LCLo (125 ppm/4H)
This review generated values consistent with Rev. 29A.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat LCLo (125 ppm/4H)
This review generated values consistent with Rev. 29A.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Lactonitrile.
Rat LCLo: American Industrial Hygiene Association Journal., 30(470), 1969 [PMID:5823428]. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Lactonitrile.