PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lithium chloride | 7447-41-8 |
15.01
4.01
14.02
4.08
4.05
7.01
8.00
7.00
11.00
4.02
|
||||||||||
| Formula | Synonyms | |||||||||||
| Li.Cl | LITHIUM CHLORIDE, LITHIUM MONOCHLORIDE | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 42.39 | S | 610 | 1350 | 1 | 547 | 2.07 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.6 | 17 | 100 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.92 | 9.8 | 58 |
Technical Basis
A review of available sources did not identify exposure limits for this chemical, but toxicity data was available including LD50 rat oral toxicity values and human oral LDLo and TDLo data. The LD50 rat oral toxicity data was selected as the basis for TEEL-3 according to the type of exposure, species, and route hierarchies discussed in Sections 3.3.1, 3.3.2. Although human data ranks highest in preference (Section 3.3.2,) the lowest published toxicity data (e.g., LDLo and TDLo) are considered less reliable as their basis is a single data point instead of multiple points (Section 3.3.1). Additionally, both human doses are from an older source (1949). Therefore, the LD50 rat oral data was selected for TEEL-3 development. TEEL-2 and TEEL-1 values were calculated according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (526 mg/kg)
This review resulted in slightly more conservative TEEL values than those published in Rev. 29A. The methodology is the same between the current recommendation and Rev. 29A (rat oral LD50,) however the previous TEEL-3 dose was 757mg/kg value, whereas a more conservative dose was selected for this review.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (526 mg/kg)
This review resulted in slightly more conservative TEEL values than those published in Rev. 29A. The methodology is the same between the current recommendation and Rev. 29A (rat oral LD50,) however the previous TEEL-3 dose was 757mg/kg value, whereas a more conservative dose was selected for this review.
References
LD50 rat, oral, dose (526 mg/kg): Acta Pharmacologica et Toxicologica., 47(351), 1980 [PMID:6270956]; via PubChem: National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 433294, Lithium Chloride. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Lithium-Chloride
LD50 rat, oral, dose (526 mg/kg): Fisher Scientific SDS: https://beta-static.fishersci.com/content/dam/fishersci/en_US/documents/programs/education/regulatory-documents/sds/chemicals/chemicals-l/S25389.pdf
LD50 rat, oral, dose (757 mg/kg): Nordic Council of Ministers/Arbetslivsinstitutet/The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals; 131 Lithium and Lithium Compounds p. 18. NR 2002:16. (2007); via PubChem: National Center for Biotechnology Information (2023). PubChem Annotation Record for , LITHIUM CHLORIDE, Source: Hazardous Substances Data Bank (HSDB). Retrieved from https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4281
Human, oral, LDLo and TD¬Lo: JAMA, Journal of the American Medical Association., 139(688), 1949 via PubChem; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 433294, Lithium Chloride. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Lithium-Chloride
LD50 rat, oral: European Patent Specification: https://patentimages.storage.googleapis.com/ce/70/69/58ebb40bd47700/EP1206567B1.pdf
LD50 rat, oral: Petersen KP. Effect of age and route of administration on LD50 of lithium chloride in the rat. Acta Pharmacol Toxicol (Copenh). 1980 Nov;47(5):351-4. doi: 10.1111/j.1600-0773.1980.tb01571.x. PMID: 6270956