A review of available sources did not identify exposure limits or acute toxicity data for lithium diisopropylamide. Reported GHS health hazard ratings (H314 and H318, Category 1) indicate a high-level health hazard, approximately equivalent to an HHR=3 (TEEL-3 = 79 mg/m3). In addition, analysts evaluated acute toxicity data (LC50, LCLo, LD50) for a similar chemical, diisopropylamine (C6H15N, CASRN: 108-18-9) for TEEL development (Section 3.4.6). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Analysts selected the most preferred species and route toxicity data for diisopropylamine, a 2-hour rat LC50, was selected as the TEEL-3 basis (Section 3.4.6). The magnitude of this TEEL-3 is supported by the GHS hazard analysis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat LC50 (diisopropylamine, CASRN: 108-18-9; 4800 mg/m3/2H)
This review generated PAC values that are inconsistent with Rev. 29A. The Rev. 29A TEEL-1 basis was a TLV-TWA for particles not otherwise specified (Section 3.5.2), from which the TEEL-2 and TEEL-3 were derived (Table 3.5). The current TEEL-3 basis is a rat LC50 for a similar chemical, diisopropylamine (Section 3.4.6, CASRN: 108-18-9), from which TEEL-2 and TEEL-1 were derived (Table 3.5).