PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Malic acid; (Malic acid, DL) 617-48-1
4.00
3.00
Formula Synonyms
C4.H6.O5
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
134.09 S 1.25
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
2.6 29 170
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.47 5.3 31
Technical Basis
A review of available sources identified acute toxicity data (LD50) for various species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The LD50 of the most preferred exposure route, a mouse oral LD50, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Mouse oral LD50 (1600 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 that was not located in this review; instead, a mouse oral LD50 was selected as the TEEL-3 basis. The Rev. 29A and current TEEL-2 and TEEL-1 methodologies remain consistent, with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Malic-Acid.
Mouse oral LD50: Kodak Company Reports., #82-0458. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Malic-Acid.
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.