PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mercaptoacetic acid; (Thioglycolic acid) | 68-11-1 | 1940 |
7.01
4.11
11.00
14.01
14.02
11.01
4.08
4.01
4.07
|
|||||||||
| Formula | Synonyms | |||||||||||
| C2.H4.O2.S | THIOGLYCOLIC ACID, 2-MERCAPTOACETIC ACID, 2-MERCAPTOETHANOIC ACID, 2-THIOGLYCOLIC ACID, ACETYL MERCAPTAN, ACIDE THIOGLYCOLIQUE (DOT FRENCH), ACIDO TIOGLICÓLICO (DOT SPANISH), ALPHA-MERCAPTOACETIC ACID, GLYCOLIC ACID, 2-THIO-, MERCAPTOACETATE, MERCAPTOACETIC ACID, SULFHYDRYLACETIC ACID, THIOGYCOLLIC ACID, THIOVANIC ACID, USAF CB-35 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 92.12 | L | -16.5 | 0.0868 | 25 | 1.325 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 3.0 | 33 | 200 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 11 | 120 | 750 |
Technical Basis
A review of available sources identified the following: TLV-TWA, LC50, and LD50. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Although inhalation is the most preferred route, the LC50 source credibility is questioned. This, and other toxicity data, were evaluated, resulting in a wide and inconsistent range of results; more specifically the estimated TEEL-3 and TEEL-2 values were overly conservative. The TLV-TWA was selected as the TEEL-1 basis, and TEEL-2/TEEL-3 values were calculated according to Table 3.5.
• TEEL-1 = TLV-TWA x 3 (1 ppm)
• TEEL-2 = TEEL-1 x 11
• TEEL-3 = TEEL-2 x 6
This review generated TEEL values that are consistent with those in Rev. 29A.
• TEEL-1 = TLV-TWA x 3 (1 ppm)
• TEEL-2 = TEEL-1 x 11
• TEEL-3 = TEEL-2 x 6
This review generated TEEL values that are consistent with those in Rev. 29A.
References
https://cameochemicals.noaa.gov/chemical/1599
American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. ACGIH, Cincinnati, OH 2014, p. 57; via PubChem: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2702#section=Occupational-Exposure-Standards
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information., OTS0554077; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 1133, Thioglycolic acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Thioglycolic-acid.
Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, 111,1982; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 1133, Thioglycolic acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Thioglycolic-acid.
Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete, 20,575,1974; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 1133, Thioglycolic acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Thioglycolic-acid.
Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, 586,1969; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 1133, Thioglycolic acid. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Thioglycolic-acid.
Sigma Aldrich SDS; https://www.sigmaaldrich.com/US/en/sds/sial/t3758