PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methyl 2-pyrrolidinone, 1-; (N-Methylpyrrolidone) | 872-50-4 |
14.01
11.01
7.01
4.01
4.09
4.07
7.11
7.10
4.08
10.00
|
||||||||||
| Formula | Synonyms | |||||||||||
| C5H9NO | N-METHYL-2-PYRROLIDONE, 1-METHYL-2-PYRROLIDINONE, 1-METHYL-2-PYRROLIDONE, 1-METHYL-5-PYRROLIDINONE, 1-METHYLAZACYCLOPENTAN-2-ONE, 1-METHYLPYRROLIDONE, AGSOLEX 1, M-PYROL, METHYLPYRROLIDONE, MICROPOSIT 2001, N 0131, N-METHYL-2-KETOPYRROLIDINE, N-METHYL-2-PYRROLIDINONE, N-METHYL-ALPHA-PYRROLIDINONE, N-METHYL-ALPHA-PYRROLIDONE, N-METHYL-GAMMA-BUTYROLACTAM, N-METHYLPYRROLIDINONE, N-METHYLPYRROLIDONE, NMP, PYROL-M | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 99.15 | L | -23.09 | 202 | 0.345 | 25 | 1.027 |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 80 | 170 | 780 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 20 | 42 | 190 |
Technical Basis
A review of available sources identified exposure limits (WEEL-TWA, OEL-STEL) and acute toxicity data (LCLo, LD50, TDLo) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The rat LCLo was considered as a TEEL-3 source but not selected because 1) the source could not be verified, and 2) the duration was not reported. Instead, analysts selected a rat oral LD50 as the TEEL-3 basis. A rat oral TDLo was selected as the TEEL-2 basis. The binding European OEL-STEL (15-minute, BOELV) was selected as the TEEL-1.
• PAC-1 = TEEL-1 = OEL-STEL (EU; 20 ppm, 80 mg/m3)
• PAC-2 = TEEL-2 = Rat oral TDLo (750 mg/kg)
• PAC-3 = TEEL-3 = Rat oral LD50 (3914 mg/kg)
This review generated PAC-2 and PAC-1 values inconsistent with Rev. 29A and a PAC-3 consistent with Rev. 29A. The Rev. 29A TEEL-2 was derived from the TEEL-3, while the current TEEL-2 is a rat toxicity data (TDLo). The Rev. 29A TEEL-1 basis was the WEEL-TWA, while the current TEEL-1 is an OEL-STEL (see Note, Table 3.5). The Rev. 29A and current TEEL-3 values, source, and methodology are consistent.
• PAC-1 = TEEL-1 = OEL-STEL (EU; 20 ppm, 80 mg/m3)
• PAC-2 = TEEL-2 = Rat oral TDLo (750 mg/kg)
• PAC-3 = TEEL-3 = Rat oral LD50 (3914 mg/kg)
This review generated PAC-2 and PAC-1 values inconsistent with Rev. 29A and a PAC-3 consistent with Rev. 29A. The Rev. 29A TEEL-2 was derived from the TEEL-3, while the current TEEL-2 is a rat toxicity data (TDLo). The Rev. 29A TEEL-1 basis was the WEEL-TWA, while the current TEEL-1 is an OEL-STEL (see Note, Table 3.5). The Rev. 29A and current TEEL-3 values, source, and methodology are consistent.
References
Chemical Information: https://pubchem.ncbi.nlm.nih.gov/compound/Methylpyrrolidone
Rat oral LD50. Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 240. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Methylpyrrolidone
Rat oral TDLo (750 mg/kg): FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20-1982- Volume(issue)/page/year: 40,1705,2002. Retrieved from: http://www.ilpi.com/dchas/2019/attachments/UY5790000.pdf
OEL-STEL(EU, 20 ppm): https://ilv.ifa.dguv.de/limitvalues/41890