PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Methyl-1-phenyl-2-pyrazolin-5-one, 3- 89-25-8
4.05
7.01
4.01
4.08
11.01
7.00
4.10
4.06
10.00
3.09
Formula Synonyms
C10H10N2O
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
174.22 Pwdr 128.9 20
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
5.7 63 380
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.80 8.8 53
Technical Basis
A review of available sources identified rat and mouse LD50 toxicity data for various routes (oral, intravenous, intraperitoneal). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The LD50 of the most preferred species and route, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1915 mg/kg)

This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was also a rat oral LD50; however, the current review used a more conservative dose. The Rev. 29A and current TEEL-2 and TEEL-1 methodology remains consistent, with differences in values due to the change of the TEEL-3 basis.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Edaravone.
Rat oral LD50: Yakuri to Chiryo. Pharmacology and Therapeutics., 25. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Edaravone
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