PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methyl-2-chloroacrylate | 80-63-7 | 8027 |
15.01
14.02
11.00
11.01
4.09
4.10
10.00
4.11
3.11
|
|||||||||
| Formula | Synonyms | |||||||||||
| C4H5ClO2 | METHYL 2-CHLOROACRYLATE, 2-CHLORO-2-PROPENOIC ACID, METHYL ESTER, 2-CHLOROACRYLIC ACID METHYL ESTER, 2-CHLOROACRYLIC ACID, METHYL ESTER, 2-PROPENOIC ACID, 2-CHLORO-, METHYL ESTER, ACRYLIC ACID, 2-CHLORO-, METHYL ESTER, METHYL 2-CHLORO-2-PROPENOATE, METHYL 2-CHLOROPROPENOATE, METHYL ALPHA-CHLOROACRYLATE, METHYL-ALPHA-CHLOROACRYLATE, PROPENOIC ACID, 2-CHLORO-, METHYL ESTER | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 120.54 | L | 140 | 12 | 25 | 1.189 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.45 | 5.0 | 17 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.091 | 1.0 | 3.4 |
Technical Basis
A review of available sources identified exposure limits (LOC, OEL-STEL and OEL-TWA), and acute toxicity data (LD50, LC50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route toxicity data, a rat LC50, was selected as the TEEL-3 basis and it was scaled to 60-minute equivalent using the ten Berge equation (Section 3.3.4). The LOC was selected as the TEEL-2. The OEL-TWA was considered as the TEEL-1 basis; however, it resulted in a TEEL-1 > TEEL-2. Instead, the TEEL-1 value was derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.005 gm/m3)
• TEEL-3 = Rat LC50 (500 mg/m3/2H)
This review resulted in TEEL values consistent with Rev. 29A. The TEEL-1 is less than 3 x TWA (Section 3.4.2); the lower value TEEL-1 was used according to Handbook guidelines (Section 4.2-4.3).
• TEEL-1 = TEEL-2/11
• TEEL-2 = LOC (0.005 gm/m3)
• TEEL-3 = Rat LC50 (500 mg/m3/2H)
This review resulted in TEEL values consistent with Rev. 29A. The TEEL-1 is less than 3 x TWA (Section 3.4.2); the lower value TEEL-1 was used according to Handbook guidelines (Section 4.2-4.3).
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/6659
OELs: https://ilv.ifa.dguv.de/limitvalues/39469
Rat LC50. Farmakologiya i Toksikologiya, 19(60), 1956. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/6659
LOC. Appendix C, pg. C-6 . https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf