PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methylamino)ethanol, 2-( | 109-83-1 | 1760 |
14.01
4.01
11.01
14.02
4.05
7.01
8.00
11.00
4.09
4.10
|
|||||||||
| Formula | Synonyms | |||||||||||
| C3.H9.N.O | METHYLETHANOLAMINE, (2-HYDROXYETHYL)METHYLAMINE, (HYDROXYETHYL)METHYLAMINE, 2-(METHYLAMINO)ETHANOL, 2-(N-METHYLAMINO)ETHANOL, 2-HYDROXY-N-METHYLETHYLAMINE, 2-HYDROXYETHYL-N-METHYLAMINE, 2-METHYLAMINO-1-ETHANOL, 2-METHYLAMINOETHANOL, 2-N-MONOMETHYLAMINOETHANOL, AMIETOL M 11, BETA-(METHYLAMINO)ETHANOL, METHYL(2-HYDROXYETHYL)AMINE, METHYL(BETA-HYDROXYETHYL)AMINE, METHYL(HYDROXYETHYL)AMINE, METHYLAMINOETHANOL, METHYLETHYLOLAMINE, MONOETHYLETHANOLAMINE, MONOMETHYL ETHANOLAMINE, MONOMETHYLAMINOETHANOL, MONOMETHYLETHANOLAMINE, MONOMETHYLMONOETHANOLAMINE, N-(2-HYDROXYETHYL)METHYLAMINE, N-METHYL ETHANOLAMINE, N-METHYL-2-AMINOETHANOL, N-METHYL-2-ETHANOLAMINE, N-METHYL-2-HYDROXYETHYLAMINE, N-METHYL-N-(2-HYDROXYETHYL)AMINE, N-METHYL-N-(BETA-HYDROXYETHYL)AMINE, N-METHYL-N-HYDROXYETHYLAMINE, N-METHYLAMINOETHANOL, N-METHYLETHANOLAMINE, N-METHYLMONOETHANOLAMINE, N-MONOMETHYLAMINOETHANOL, N-MONOMETHYLETHANOLAMINE, USAF DO-50 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 75.11 | L | 156 | 0.7 | 20 | 0.937 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 5.6 | 62 | 370 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 1.8 | 20 | 120 |
Technical Basis
A review of available sources identified acute toxicity data (LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Analysts evaluated three rat oral LD50 sources; analysts selected the lowest reported dose for combined sexes (1880 mg/kg) as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1880 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 (1391 mg/kg); analysts did evaluate this dose was for female rats only. Instead, the current TEEL-3 basis is a combined oral LD50 for male and female rats. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
• PAC-1 = TEEL-1 = TEEL-2/11
• PAC-2 = TEEL-2 = TEEL-3/6
• PAC-3 = TEEL-3 = Rat oral LD50 (1880 mg/kg)
This review generated PAC values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was a rat oral LD50 (1391 mg/kg); analysts did evaluate this dose was for female rats only. Instead, the current TEEL-3 basis is a combined oral LD50 for male and female rats. The Rev. 29A and current TEEL-2 and TEEL-1 use the same methodology, with differences due to the change in TEEL-3.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/8016
Rat oral LD50 (1391 mg/kg). O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1117. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128
Rat oral LD50 (2340 mg/kg). O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1117. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128
LD50 rat oral (1880 mg/kg). Retrieved from: https://chem.echa.europa.eu/100.003.374/dossier-view/bae0f2d5-e7e8-472d-9808-4e850ee32cfd/IUC5-99c85b58-3df2-4478-960a-5e6237dba6a8_2538abca-8a13-4092-a14d-7854d9484437?searchText=109-83-1