PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methylene bis(2-chloroaniline), 4,4'-; (MBOCA) | 101-14-4 |
13.00
4.01
7.01
11.00
4.02
4.09
4.06
4.10
4.07
4.03
|
||||||||||
| Formula | Synonyms | |||||||||||
| C13H12Cl2N2 | 4,4^-METHYLENEBIS(2-CHLOROANILINE), 3,3'-DICHLORO-4,4'-DIAMINODIPHENYLMETHANE, 4,4'-DIAMINO-3,3'-DICHLORODIPHENYLMETHANE, 4,4'-METHYLENE(BIS)CHLOROANILINE, 4,4'-METHYLENEBIS(2-CHLORANILINE), 4,4'-METHYLENEBIS(2-CHLOROBENZENAMINE), 4,4'-METHYLENEBIS(O-CHLORO ANILINE), 4,4'-METHYLENEBIS(O-CHLOROANILINE), 4,4'-METHYLENEBIS-2-CHLOROBENZENAMINE, 4,4'-METHYLENEBIS[2-CHLOROANILINE], 4,4'-METHYLENEBIS[O-CHLOROANILINE], ANILINE, 4,4'-METHYLENEBIS[2-CHLORO-, BIS AMINE, BIS(3-CHLORO-4-AMINOPHENYL)METHANE, BIS(4-AMINO-3-CHLOROPHENYL)METHANE, BIS-AMINE A, BISAMINE S, CL-MDA, CUAMINE M, CUAMINE MT, CURALIN M, CURENE 442, CYANASET, DACPM, DI(4-AMINO-3-CHLOROPHENYL)METHANE, DIAMET KH, DIAMET X, MBOCA, METHYLENE 4,4'-BIS(O-CHLOROANILINE), METHYLENE-BIS-ORTHOCHLOROANILINE, METHYLENEBIS(3-CHLORO-4-AMINOBENZENE), METHYLENEBIS(O-CHLOROANILINE), MILLIONATE M, MOCA, MOCA (CURING AGENT), P,P'-METHYLENEBIS(ALPHA-CHLOROANILINE), P,P'-METHYLENEBIS(O-CHLOROANILINE), QUODOROLE, RCRA WASTE NUMBER U158 | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 267.15 | S | 110 | 25 | 1.44 no temp |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.33 | 10 | 230 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.030 | 0.92 | 21 |
Technical Basis
A review of available sources identified the following: TLV-TWA, LD50 (guinea pig, mouse, rat,) and TDLo (mouse, rat,) toxicity data for oral and intraperitoneal routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The rat LD50 was selected as the TEEL-3 basis because rats are the most preferred species out of the data obtained. The mouse TDLo was selected for TEEL-2, as it was an acute exposure with appropriate toxic endpoints for TEEL development (Methemoglobinemia- Carboxhemoglobinemia, which can cause cyanosis, fatigue, headache, seizures, potentially impeding escape). The TLV-TWA was selected as the TEEL-1 basis.
• TEEL-1 = TLV-TWA (0.01 ppm) x 3
• TEEL-2 = Mouse oral TDLo (83 mg/kg)
• TEEL-3 = Rat oral LD50 (1140 mg/kg)
This review generated values that are consistent with those published in Rev. 29A.
• TEEL-1 = TLV-TWA (0.01 ppm) x 3
• TEEL-2 = Mouse oral TDLo (83 mg/kg)
• TEEL-3 = Rat oral LD50 (1140 mg/kg)
This review generated values that are consistent with those published in Rev. 29A.
References
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 7543, 4,4'-Methylenebis(2-chloroaniline). Retrieved April 10, 2023 from https://pubchem.ncbi.nlm.nih.gov/compound/4_4_-Methylenebis_2-chloroaniline
TLV-TWA: American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. ACGIH, Cincinnati, OH 1991. Source: Occupational Safety and Health Administration. Retrieved from: https://www.osha.gov/chemicaldata/22
Guinea pig, oral LD50; Mouse oral LD50; Rat oral LD50: Gigiena i Sanitariya. For English translation, see HYSAAV., 55(6)(86), 1990; National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 7543, 4,4'-Methylenebis(2-chloroaniline). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/4_4_-Methylenebis_2-chloroaniline
Mouse oral TDLo: HPV076, 2005; https://www.cdc.gov/niosh-rtecs/CY100590.html
Rat intraperitoneal TDLo: WDZAEK 7,30,1993; https://www.cdc.gov/niosh-rtecs/CY100590.html