PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Methylphosphonothioic acid, S-(2-(dimethylamino)ethyl) O-ethyl ester | 20820-80-8 |
4.00
3.00
|
||||||||||
| Formula | Synonyms | |||||||||||
| C7.H18.N.O2.P.S | ||||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 211.29 | L |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.00037 | 0.004 | 0.024 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.000043 | 0.00046 | 0.0028 |
Technical Basis
A review of available sources identified rat and mouse LD50 toxicity data for multiple routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. The most preferred species and route, a rat oral LD50, was selected as the TEEL-3 basis. TEEL-1 and TEEL-2 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (122 µg/kg => 0.122 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was mouse intravenous LD50, however the recommended basis, a rat oral LD50, is a more preferred species (rat > mouse) and route (oral > intravenous). The TEEL-2 and TEEL-1 methodologies remain the same, with the differences in values due to the change in the TEEL-3 basis.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Rat oral LD50 (122 µg/kg => 0.122 mg/kg)
This review generated TEEL values inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis was mouse intravenous LD50, however the recommended basis, a rat oral LD50, is a more preferred species (rat > mouse) and route (oral > intravenous). The TEEL-2 and TEEL-1 methodologies remain the same, with the differences in values due to the change in the TEEL-3 basis.
References
Rat oral LD50: Acta Biologica et Medica Germanica., 37(633), 1978 [PMID:735630]. Retrieved from: National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 102302, Medemo. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Medemo
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Medemo.