PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Methyltetrahydrofuran, 2- 96-47-9
16.01
11.01
15.02
Formula Synonyms
C5.H10.O
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
86.15 L 80 0.853 @ 20°C
PAC Values
PAC Values (Original Units: ppm)
PAC-1 PAC-2 PAC-3
4.0 44 270
Converted PAC Values (mg/m3)
PAC-1 PAC-2 PAC-3
14 160 950
Technical Basis
A review of available sources identified an LC50. Due to the limited sources, this review also evaluated TLV-TWA and LC50 exposures for a similar chemical: Tetradhydrofuran (THF, CASRN: 109-99-9.) Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and factors in Tables 3.2, 3.3, and 3.4. The LC50 for the chemical of interest was selected as the basis for the TEEL-3 estimate; evaluation of compound adjusted THF exposures resulted in a higher TEEL-3 estimate and was not used. The concentration was time-scaled to a 60-minute basis using the ten Berge equation (Section 3.3.4). TEEL-2 and TEEL-1 estimates were calculated from this TEEL-3 value, according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-3/6
• TEEL-3 = Estimated from rat 4-hr LC50 (6000 ppm)
This review generated TEEL values consistent with those published in Rev. 29A.
References
https://cameochemicals.noaa.gov/chemical/3972
Rat, 4-hr LC50: Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969, -(395), 1969; via PubChem from https://pubchem.ncbi.nlm.nih.gov/compound/2-Methyltetrahydrofuran
1993-1994 ACGIH TLV-TWA; https://www.cdc.gov/niosh/idlh/109999.html
Rat, 3-hr LC50: Horiguchi et al. 1984; via CDC: https://www.cdc.gov/niosh/idlh/109999.html
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.