PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Anisole; (Anisole anhydrous; Methoxybenzene) 100-66-3 2222
15.01
11.01
15.02
7.01
8.00
11.00
4.09
4.10
4.07
3.09
Formula Synonyms
C7H8O ANISOLE, ANISOL, ANISOL (DOT SPANISH), ANISOLE (DOT FRENCH), METHOXYBENZENE, METHYL PHENYL ETHER, PHENOXYMETHANE, PHENYL METHYL ETHER
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
108.15 L -37.3 153.8 10 42.2 1.515
PAC Values
PAC Values (Original Units: mg/m3)
PAC-1 PAC-2 PAC-3
1.6 18 110
Converted PAC Values (ppm)
PAC-1 PAC-2 PAC-3
0.36 4.1 25
Technical Basis
A review of available sources identified rat and mouse acute toxicity data (LC50, LD50). Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). The rat LC50 study reported no deaths; instead, the mouse LC50 was selected as the TEEL-3 basis. TEEL-2 and TEEL-1 values were derived according to Table 3.5.
• TEEL-1 = TEEL-2/11
• TEEL-2 = TEEL-2/6
• TEEL-3 = Mouse LC50 (3021 mg/kg/2H)
This review generated TEEL values that are consistent with Rev. 29A*.
References
Chemical Information. https://pubchem.ncbi.nlm.nih.gov/compound/Anisole
Rat Inhalation LC50 (6.51 mg/kg/4hr): Retrieved from: https://echa.europa.eu/lv/registration-dossier/-/registered-dossier/14423/7/3/3
Mouse Inhalation LC50 (3021 mg/kg/2H). Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases., 28(6)(43), 1984. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Anisole
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PAC values marked with a subscript "A" correspond to 60-minute AEGL values.
PAC values marked with a subscript "E" correspond to ERPG values.
PAC values marked by * are >= 10% lower explosive limit (LEL) but < 50% LEL.
PAC values marked by ** are > 50% LEL but < 100% LEL.
PAC values marked by *** are >= LEL.