PAC Database - Detailed Chemical Data
Chemical Identity
| Chemical | CAS# | UN# | Health Code Numbers | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Monocrotophos | 6923-22-4 | 2783 |
6.00
15.01
11.01
8.00
7.01
7.00
4.01
4.05
4.08
11.00
|
|||||||||
| Formula | Synonyms | |||||||||||
| C7H14NO5P | MONOCROTOPHOS, (E)-DIMETHYL 1-METHYL-3-(METHYLAMINO)-3-OXO-1-PROPENYL PHOSP, (E)-PHOSPHORIC ACID DIMETHYL ESTER, ESTER WITH 3-HYDROXY-N-M, 3-(DIMETHOXYPHOSPHINYLOXY) N-METHYL-CIS-CROTONAMIDE, 3-(DIMETHOXYPHOSPHINYLOXY)-N-METHYL-CIS-CROTONAMIDE, 3-(DIMETHOXYPHOSPHINYLOXY)-N-METHYLISOCROTONAMIDE, 3-HYDROXY-N- METHYLCROTONAMIDE DIMETHYL PHOSPHATE, 3-HYDROXY-N-METHYL-CIS-CROTONAMIDE DIMETHYL PHOSPHATE, 3-HYDROXY-N-METHYLCROTONAMIDE DIMETHYLPHOSPHATE, APADRIN, AZODRIN, AZODRIN 202R, AZODRIN 60, AZODRIN INSECTICIDE, BILOBRAN, C 1414, CIBA 1414, CIS-1-METHYL-2-METHYL CARBAMOYL VINYL PHOSPHATE, COROPHOS, CRISODRIN, CROTON 36, CROTONAMIDE, 3-HYDROXY-N-METHYL-, DIMETHYLPHOSPHATE,(E)-, DIMETHYL 1-METHYL-2-(METHYLCARBAMOYL)VINYL PHOSPHATE, CIS-, DIMETHYL 2-METHYLCARBAMOYL-1- METHYLVINYL PHOSPHATE, DIMETHYL PHOSPHATE ESTER OF 3-HYDROXY-N-METHYL-CIS- CROTONAM, DIMETHYL PHOSPHATE OF 3-HYDROXY-N-METHYL-CIS-CROTONAMIDE, ENT 27,129, MONICIL, MONOCIL, MONOCIL 40, MONOCOS, MONOCRON, MONOSTAR, N-DESMETHYL BIDRIN, N-METHYL BIDRIN, NUVACRON, NUVACRON 20, NUVACRON 36SL, PARRYFOS, PHOSPHORIC ACID, DIMETHYL 1-METHYL-3-(METHYLAMINO)-3-OXO-1-P, PHOSPHORIC ACID, DIMETHYL 1-METHYL-3-(METHYLAMINO)-3-OXO-1-P, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH 3-HYDROXY-N- MET, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH 3-HYDROXY-N-METH, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH CIS-3- HYDROXY-N, PHOSPHORIC ACID, DIMETHYL ESTER, ESTER WITH(E)-3-HYDROXY-N-, PILLARDRIN, PLANTDRIN, SD 9129, SHELL SD 9129, SUSVIN | |||||||||||
Physical Properties
| Mol Wt | State | MP (°C) | BP (°C) | VP (Hg) | VP (°C) | SG | LEL (ppm) |
|---|---|---|---|---|---|---|---|
| 223.19 | S | 125 | 0.000007 | 25 | 1.22 @ 20°C |
PAC Values
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.15 | 0.63 | 2.7 |
| PAC-1 | PAC-2 | PAC-3 |
|---|---|---|
| 0.016 | 0.069 | 0.30 |
Technical Basis
A review of available sources identified exposure limits (LOC, STEL, TWAs) and acute toxicity data (LC50, LD50) for several species and routes. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Inhalation exposures were scaled to 60-minute equivalents using the ten Berge equation (Section 3.3.4). Analysts evaluated available rat inhalation sources selected the lowest 1-hour rat LC50 (Section 3.3.2) form the most reliable source as the TEEL-3 basis (Section 3.3.1).
• TEEL-1 = TLV-TWA (0.05 mg/m3) x 3
• TEEL-2 = LOC (0.00063 gm/m3)
• TEEL-3 = Rat LC50 (94 mg/m3/1H)
This review generated a TEEL-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis, a 4-hour rat LC50, was found during the review, but was determined that there were insufficient study details available. Instead, analyst selected the lowest 1-hr LC50 as the TEEL-3. The Rev. 29A and current TEEL-2 and TEEL-1 values, source, and methodology are consistent.
• TEEL-1 = TLV-TWA (0.05 mg/m3) x 3
• TEEL-2 = LOC (0.00063 gm/m3)
• TEEL-3 = Rat LC50 (94 mg/m3/1H)
This review generated a TEEL-3 value inconsistent with Rev. 29A. The Rev. 29A TEEL-3 basis, a 4-hour rat LC50, was found during the review, but was determined that there were insufficient study details available. Instead, analyst selected the lowest 1-hr LC50 as the TEEL-3. The Rev. 29A and current TEEL-2 and TEEL-1 values, source, and methodology are consistent.
References
Chemical information: https://pubchem.ncbi.nlm.nih.gov/compound/Monocrotophos
Rat LC50 (63 mg/mg/m3 /4H). Egeszsegtudomany., 24(173), 1980. Retrieved from: https://pubchem.ncbi.nlm.nih.gov/compound/Monocrotophos
Rat LC50 (94 mg/m3/1H). Refer to Section 3.1.1 (pg. 10-11) for discussion of the 63 mg/m3/4H dose reliability. Refer to pg. 6 and 10 (Table 2) for summary of data. Report retrieved from: https://19january2017snapshot.epa.gov/sites/production/files/2014-11/documents/monocrotophos_proposed_oct_2009.v1.pdf
Exposure limits: https://www.osha.gov/chemicaldata/487
OELs: https://ilv.ifa.dguv.de/limitvalues/42655
LOC. Appendix C, pg. C-6. https://www.epa.gov/sites/default/files/2015-09/documents/technical_guidance_for_hazard_analysis.pdf