PAC Database - Detailed Chemical Data

Chemical Identity
Chemical CAS# UN# Health Code Numbers
Nickel carbonate hydroxide; (Basic nickel(II) carbonate) 12607-70-4

Formula Synonyms
Physical Properties
Mol Wt State MP (°C) BP (°C) VP (Hg) VP (°C) SG LEL (ppm)
304.18 S 2.6
PAC Values
PAC Values (Original Units: mg/m3)
1.0 22 130
Converted PAC Values (ppm)
0.080 1.8 10
Technical Basis
No data is available for nickel carbonate hydroxide; nickel (CAS: 7440–02–0) and nickel carbonate hydroxide, tetrahydrate (CAS: 39430-27-8) were investigated. From the California Office of Environmental Health Hazard Assessment (OEHHA, Feb. 2012), nickel and nickel compound toxicity were discussed, and it was noted that water solubility has a significant effect on chemical uptake and tissue distribution. Water soluble compounds were found in 10-to-100-fold higher concentrations in the body than water insoluble compounds (such as nickel carbonate hydroxide). As similar structures and elemental components were investigated, solubility was also examined. Data sources were selected according to the hierarchy listed in Table 3.1. Toxicity data were selected according to type of exposure, species, and route according to the hierarchies stated in Sections 3.3.1, 3.3.2, and evaluated using factors in Tables 3.2, 3.3, and 3.4. Compound adjustments were applied where appropriate (3.2.2).
Nickel IDLHs and nickel carbonate hydroxide, tetrahydrate toxicity dosages were evaluated as TEEL-3 bases. The 1990 IDLH has no evidence, with an effective limit of 2000 mg/m3 based on the OSHA PEL-TWA. The 1994 IDLH limit basis was a mouse 10-min LCLo concentration for nickel fluoroborate (CAS: 14708-14-6,) a water-soluble compound. Given the unsuitability of available IDLH, a rat oral LD50 dosage for nickel carbonate hydroxide, tetrahydrate (insoluble) was selected as the TEEL-3 basis and a compound adjust factor applied. For TEEL-2, a Level of Concern was found for nickel. The TEEL-2 was derived according to Table 3.5. A TLV-TWA for insoluble nickel was selected as the TEEL-1 basis and a compound adjustment factor was applied.
• TEEL-1 = MW-adjusted TLV-TWA x 3 (Ni, 0.2 mg/m3, CASRN: 7440-02-0)
• TEEL-2 =TEEL-3/6
• TEEL-3 = MW-adjusted rat oral LD50 (840 mg/kg, nickel carbonate hydroxide, tetrahydrate, CASRN: 39430-27-8)
This review generated a TEEL-1 value that is consistent with Rev. 29A. The TEEL-3 and TEEL-2 values are less conservative than those in Rev. 29A, where the TLV-TWA was previously adjusted according to Table 3.5. Less conservatism appears to be appropriate based on the toxicity of comparable insoluble nickel compounds.
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 25559, Basic nickel(II) carbonate. Retrieved from
American Conference of Governmental Industrial Hygienists TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH, 2008, p. 43. Retrieved from
Sigma Aldrich SDS, Ver. 6.4 (4/21/22);
NIOSH. NIOSH Pocket Guide to Chemical Hazards. DHHS (NIOSH) Publication No. 97-140. Washington, D.C. U.S. Government Printing Office, 1997., p. 224; National Center for Biotechnology Information (2023). PubChem Annotation Record for BASIC NICKEL(II) CARBONATE, Source: Hazardous Substances Data Bank (HSDB). Retrieved from Another link:
National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 76955832, Basic nickel carbonate tetrahydrate. Retrieved from
Nickel And Nickel Compounds; via OEHHA:
Technical Guidance for Hazards Analysis; via EPA:
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